5-HT2C receptor involvement in female rat lordosis behavior
Autor: | Lynda Uphouse, Mini DeLashaw, Amy Wolf, Marjay Caldarola-Pastuszka |
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Rok vydání: | 1999 |
Předmět: |
medicine.medical_specialty
Indoles Ketanserin Pyridines medicine.drug_class Ovariectomy Posture Sexual Behavior Animal chemistry.chemical_compound Piperidines Internal medicine Receptor Serotonin 5-HT2C medicine Animals Molecular Biology Estradiol Chemistry General Neuroscience Rats Inbred Strains Receptor antagonist Lordosis behavior Rats Serotonin Receptor Agonists Fluorobenzenes 5-HT2C receptor Indophenol Endocrinology Ventromedial nucleus of the hypothalamus Ventromedial Hypothalamic Nucleus Hypothalamus Receptors Serotonin Ovariectomized rat Estradiol benzoate Female Serotonin Antagonists Neurology (clinical) Developmental Biology medicine.drug |
Zdroj: | Brain Research. 825:146-151 |
ISSN: | 0006-8993 |
Popis: | Adult, hormone-primed, ovariectomized rats (CDF-344) with bilateral implants within the ventromedial nucleus of the hypothalamus (VMN), were injected with 0.5 microgram estradiol benzoate followed 48 h later with 500 microgram progesterone. This priming produced rats with 2 different levels of sexual receptivity. Rats with a lordosis to mount ratio (L/M)/=0.5 were used to examine the potential lordosis-inhibiting effects of the 5-HT2A receptor antagonist, R(+)-a-(2, 3-dimethoxyphenyl)-1-[2(4-fluoro-phenylethyl)]-4-piperidine-methanol (MDL 100,907), and the 5-HT2C receptor antagonist, 5-methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2, 3-f]indole (SB 206553). Rats with low sexual receptivity (L/M0.5) were bilaterally infused with the 5-HT2A/2C receptor agonist, (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI), or DOI plus either MDL 100,907 or SB 206553 to determine if either drug would attenuate the lordosis-facilitating effects of DOI. The 5-HT2C receptor antagonist, but not the 5-HT2A receptor antagonist, effectively inhibited lordosis behavior. Similarly, SB 206553 was more effective than MDL 100,907 in reducing the DOI-induced increase in lordosis responding. However, both drugs limited the duration of lordosis responding initiated by DOI. These results are consistent with prior suggestions that 5-HT2A/2C receptors within the VMN are involved in the modulation of lordosis behavior and lead to the suggestion that 5-HT2C, rather than 5-HT2A, receptors are primarily responsible for the effects of 5-HT2 receptor-active drugs on lordosis behavior. |
Databáze: | OpenAIRE |
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