Analysis of Immune-Relevant Genes Expressed in Spleen of Capra hircus Kids Fed with Trivalent Chromium
| Autor: | Mostafa Sadeghi, Mohammad Javad Najafpanah |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism Clinical Biochemistry chemistry.chemical_element Spleen Biology Biochemistry Inorganic Chemistry Andrology chemistry.chemical_compound Chromium Immune system Immunity Chromium Compounds Histocompatibility Antigens Gene expression medicine Capra hircus Animals Humans Lymphocytes Methionine Goats Biochemistry (medical) General Medicine Real-time polymerase chain reaction medicine.anatomical_structure Gene Expression Regulation chemistry Dietary Supplements Immunology Female |
| Zdroj: | Biological Trace Element Research. 156:124-129 |
| ISSN: | 1559-0720 0163-4984 |
| Popis: | Chromium is a biologically important element for humans and laboratory animals. Although the favorable effects of trivalent chromiumon immune responses of studied animals have been well documented, the precise mechanisms by which the chromium acts on immune system is relatively poor studied. In this study, real-time qPCR technique was employed to evaluate the expression profiles of four immune-related genes (B2M, MHCA, MHCB, and Rap2A) in spleens of the domestic goats, Capra hircus, feeding on four different levels of supplemental chromium (0, 0.5, 1, and 1.5 mg/day) as chromium– methionine. The results showed that 1.5 mg/day of supplemental chromium significantly increased the expression of the four studied genes (P |
| Databáze: | OpenAIRE |
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