SATB1 in Malignant T Cells
| Autor: | Claudia Nastasi, Tengpeng Hu, Andreas Willerslev-Olsen, Edda Blümel, Terkild B. Buus, Christina Friese, Thorbjørn Krejsgaard, Sergei B. Koralov, Mariusz A. Wasik, Niels Ødum, Jenny L. Persson, Sarah L. Mathiasen, Maria Gluud, Özcan Met, David L. Petersen, Katharina L. Kopp, Linda Kubat, Anders Woetmann, Simon Fredholm, Charlotte M. Bonefeld, Lise M. Lindahl, Jürgen C. Becker, Carsten Geisler, Lars Iversen |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Skin Neoplasms T-Lymphocytes Biochemistry ACTIVATION STAT3 Cohort Studies 0302 clinical medicine PROGNOSTIC-FACTORS SEQUENCE-BINDING PROTEIN-1 hemic and lymphatic diseases LYMPHOMA-CELLS STAT5 Transcription Factor RNA Small Interfering STAT5 Regulation of gene expression biology Janus kinase 3 MYCOSIS-FUNGOIDES Gene Expression Regulation Neoplastic Thymocyte 030220 oncology & carcinogenesis Gene Knockdown Techniques Disease Progression MULTIPLE GENES Signal transduction Signal Transduction Dermatology 03 medical and health sciences Mycosis Fungoides Cell Line Tumor medicine Humans Interleukin 9 Molecular Biology Neoplasm Staging Mycosis fungoides MICRORNA EXPRESSION Cutaneous T-cell lymphoma Interleukin-9 Janus Kinase 3 Cell Biology Matrix Attachment Region Binding Proteins medicine.disease MicroRNAs 030104 developmental biology Cancer research biology.protein OVEREXPRESSION Interleukin-5 GASTRIC-CANCER |
| Zdroj: | Fredholm, S, Willerslev-Olsen, A, Met, Ö, Kubat, L, Gluud, M, Mathiasen, S L, Friese, C, Blümel, E, Petersen, D L, Hu, T, Nastasi, C, Lindahl, L M, Buus, T B, Krejsgaard, T, Wasik, M A, Kopp, K L, Koralov, S B, Persson, J L, Bonefeld, C M, Geisler, C, Woetmann, A, Iversen, L, Becker, J C & Odum, N 2018, ' SATB1 in Malignant T Cells ', Journal of Investigative Dermatology, vol. 138, no. 8, pp. 1805-1815 . https://doi.org/10.1016/j.jid.2018.03.1526 |
| ISSN: | 1523-1747 |
| DOI: | 10.1016/j.jid.2018.03.1526 |
| Popis: | Deficient expression of Suppressor Special AT-rich Binding-1 (SATB1) hampers thymocyte development and results in inept T cell lineages. Recent data implicate dysregulated SATB1 expression in the pathogenesis of mycosis fungoides (MF), the most frequent variant of cutaneous T cell lymphoma (CTCL). Here we report on a disease-stage-associated decrease of SATB1 expression and an inverse expression of STAT5 and SATB1 in situ. Importantly, STAT5 inhibited SATB1 expression through induction of miR-155. Decreased SATB1 expression triggered enhanced expression of IL-5 and IL-9 (but not IL-6 and IL-32) whereas increased SATB1 expression had the opposite effect indicating that the mir-155 target SATB1 is a repressor of IL-5 and IL-9 in malignant T cells. In accordance, inhibition of STAT5, and its upstream activator Janus Kinase-3 (Jak3), triggered increased SATB1 expression and a concomitant suppression of IL-5 and IL-9 expression in malignant T cells. In conclusion, we provide a mechanistic link between the proto-oncogenic Jak3/STAT5/miR-155 pathway, SATB1, and cytokines linked to CTCL severity and progression indicating that SATB1 dysregulation is involved in CTCL pathogenesis. |
| Databáze: | OpenAIRE |
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