Prevalence and development of antibodies neutralizing the haemolysin and cytotoxin ofactinobacillus pleuropneumoniaein three infected pig herds
| Autor: | A. Bartelse, J. H. M. Verheijden, W.A. Hunneman, K. Riepema, E.M. Kamp, L. A. M. G. van Leengoed, T. Cruijsen |
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| Rok vydání: | 1995 |
| Předmět: |
Serotype
Swine animal diseases Neutralization Disease Outbreaks Microbiology Hemolysin Proteins Actinobacillus Infections Neutralization Tests Prevalence medicine Animals Cytotoxic T cell Longitudinal Studies Actinobacillus pleuropneumoniae Swine Diseases General Veterinary biology Cytotoxins Complement Fixation Tests Hemolysin medicine.disease biology.organism_classification Antibodies Bacterial Virology Cross-Sectional Studies biology.protein Pleuropneumonia Antibody |
| Zdroj: | Veterinary Quarterly. 17:96-100 |
| ISSN: | 1875-5941 0165-2176 |
| DOI: | 10.1080/01652176.1995.9694541 |
| Popis: | Sero-epidemiological studies were carried out in pigs aged 1 to 24 weeks in three herds in which Actinobacillus pleuropneumoniae was endemic. The sera were tested in the complement-fixation test and for their ability to neutralize the haemolytic and cytotoxic activities of the A. pleuropneumoniae serotypes isolated from the herds. Almost all (98%) sera from 1-week-old piglets neutralized the haemolytic and cytotoxic activities but only 21% fixed complement. At the end of the finishing period, most pigs (82%) had sera that neutralized haemolytic and cytotoxic activities and only 22% fixed complement. In longitudinal studies the neutralization titres decreased during the first 12-13 weeks of age. Thereafter, 75% of the pigs had increased titres in the haemolysin- and cytotoxin-neutralization tests and only 5% of the pigs had increased titres in the complement-fixation test. In none of these pigs were clinical signs of pleuropneumonia seen. Thus in these endemically infected herds the prevalence of complement-fixing antibodies was low, whereas the prevalence of neutralizing antibodies was high. The fact that serum-neutralizing titres are low in 12-week-old pigs might be the reason that pigs of this age are the most vulnerable to the disease. |
| Databáze: | OpenAIRE |
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