New endometrial immune cell-based score (EI-score) for the prediction of implantation success for patients undergoing IVF/ICSI
| Autor: | Yuye Li, Longfei Li, Songchen Cai, Lianghui Diao, Yong Zeng, Linlin Wang, Shuyi Yu, Chunyu Huang, Su Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Oncology medicine.medical_specialty T-Lymphocytes medicine.medical_treatment Fertilization in Vitro Intracytoplasmic sperm injection Natural killer cell Endometrium Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Cytotoxic T cell Embryo Implantation Sperm Injections Intracytoplasmic 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry Macrophages Obstetrics and Gynecology FOXP3 Retrospective cohort study Dendritic Cells Nomogram Prognosis 030104 developmental biology medicine.anatomical_structure Reproductive Medicine Female business CD8 Developmental Biology |
| Zdroj: | Placenta. 99:180-188 |
| ISSN: | 0143-4004 |
| DOI: | 10.1016/j.placenta.2020.07.025 |
| Popis: | Problem Limited evidence revealed whether endometrial immunological factors contribute to implantation success in the first-attempted in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) patients. Method The retrospective study was conducted among 139 eligible couples in the derivation cohort and 29 couples in the validation cohort. The expression of endometrial immune cell markers, including CD56 for natural killer cell, CD68 for pan-macrophage, CD163 for M2 macrophage, FOXP3 for regulatory T cell, CD1a for immature dendritic cell, CD83 for mature dendritic cell, CD8 for cytotoxic T cell and CD57 for mature NK and T cells were examined. Results The profiles of endometrial immune cells showed significant difference between the pregnant and implantation failure group in the derivation cohort. Multivariate logistic regression analysis showed that the percentage of CD68+ pan-macrophage and CD163+ M2-macrophage, as well as the transfer strategy are associated with implantation outcomes (P Conclusions The endometrial immunological profiles in the mid-secretory phase is associated with implantation outcome in the first IVF/ICSI patients. EI-Score could help clinicians calculate the probability of implantation success via nomogram. Optimal decision point is determined by decision curve analysis and clinical impact curve, to aid in clinical decisions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect