Esophagogastric metaplasia relates to nodal metastases in adenocarcinoma of esophagus and cardia
| Autor: | Deborah Malvi, Giandomenico Raulli, Ottorino Perrone, Alberto Ruffato, Marialuisa Lugaresi, Luca Frassineti, Antonietta D'Errico, Maria Rosaria Aprile, Massimo Pierluigi Di Simone, Sandro Mattioli |
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| Přispěvatelé: | Ruffato A., Mattioli S., Perrone O., Lugaresi M., Di Simone M.P., D'Errico A., Malvi D., Aprile M.R., Raulli G., Frassineti L. |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology Esophageal Neoplasms medicine.medical_treatment BARRETT’S ESOPHAGUS Multimodal Imaging Gastroenterology Metaplasia hemic and lymphatic diseases Medicine Endoscopy Digestive System Prospective Studies Intestinal Mucosa ADENOCARCINOMA OF THE CARDIA Stomach ADENOCARCINOMA OF THE ESOPHAGUS Anastomosis Surgical Intestinal metaplasia Cardia Middle Aged Prognosis Jejunum medicine.anatomical_structure Esophagectomy Lymphatic Metastasis Adenocarcinoma Female medicine.symptom biological phenomena cell phenomena and immunity Cardiology and Cardiovascular Medicine Pulmonary and Respiratory Medicine medicine.medical_specialty education Barrett Esophagus Esophagus Gastrectomy Stomach Neoplasms Internal medicine Humans GASTRO-INTESTINAL METAPLASIA neoplasms Aged business.industry medicine.disease digestive system diseases GASTRIC CANCER Positron-Emission Tomography Barrett's esophagus Surgery Lymphadenectomy Lymph Nodes Tomography X-Ray Computed business |
| Popis: | BACKGROUND: Immunohistochemical profiles of esophageal and cardia adenocarcinoma differ according to the presence or absence of Barrett's epithelium (BIM) and gastric intestinal metaplasia (GIM) in the fundus and antrum. Different lymphatic spreading has been demonstrated in esophageal adenocarcinoma. We investigated the correlation among the presence or absence of intestinal metaplasia in the esophagus and stomach and lymphatic metastases in patients who underwent radical surgery for esophageal and cardia adenocarcinoma. METHODS: The mucosa surrounding the adenocarcinoma and the gastric mucosa were analyzed. The BIM+ patients underwent subtotal esophagectomy and gastric pull up, and the BIM- patients underwent esophagectomy at the azygos vein, total gastrectomy, and esophagojejunostomy. The radical thoracic (station numbers 2, 3, 4R, 7, 8, and 9) and abdominal (station numbers 15 through 20) lymphadenectomy was identical in both procedures except for the greater curvature. RESULTS: One hundred ninety-four consecutive patients were collected in three major groups: BIM+/GIM-, 52 patients (26.8%); BIM-/GIM-, 90 patients (46.4%); BIM-/GIM+, 50 patients (25.8%). Two patients (1%) were BIM+/GIM+. A total of 6,010 lymph nodes were resected: 1,515 were recovered in BIM+, 1,587 in BIM-/GIM+, and 2,908 in BIM-/GIM- patients. The percentage of patients with pN+ stations 8 and 9 was higher in BIM+ (p = 0.001), and the percentage of patients with pN+ perigastric stations was higher in BIM- (p = 0.001). The BIM-/GIM- patients had a number of abdominal metastatic lymph nodes higher than did the BIM-/GIM+ patients (p = 0.0001). CONCLUSIONS: According to the presence or absence of BIM and GIM in the esophagus and cardia, adenocarcinoma correspond to three different patterns of lymphatic metastasization, which may reflect different biologic and carcinogenetic pathways. |
| Databáze: | OpenAIRE |
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