Regulatory T and B cells in peripheral blood of subcutaneous immunotherapy-treated Japanese cedar pollinosis patients
| Autor: | Nau Tsujimoto, Shuji Omura, Yusuke Ayani, Yuki Tabuchi, Tomoki Ishida, Tetsuya Terada, Keiki Noro, Kana Doi, Yuki Morie, Takahiro Ichihara, Yuko Inaka, Yusuke Kikuoka, Takeshi Nabe, Masaya Matsuda, Junpei Hamaguchi, Ryo Kawata, Takuya Yoshida, Manabu Suzuki, Takaki Inui, Hiromu Takahashi |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Allergy Clinical immunology Cryptomeria Injections Subcutaneous medicine.medical_treatment Immunology T-Lymphocytes Regulatory Peripheral blood mononuclear cell Young Adult 03 medical and health sciences 0302 clinical medicine Subcutaneous immunotherapy Humans Immunology and Allergy Medicine Aged Aged 80 and over B-Lymphocytes Regulatory Messenger RNA business.industry Rhinitis Allergic Seasonal Cedar pollinosis Immunotherapy Allergens Antigens Plant Middle Aged medicine.disease Peripheral blood Interleukin-10 Basic-Leucine Zipper Transcription Factors 030104 developmental biology Oncology Desensitization Immunologic 030220 oncology & carcinogenesis Blood Circulation Pollen Female business Biomarkers |
| Zdroj: | Immunotherapy. 11:473-482 |
| ISSN: | 1750-7448 1750-743X |
| DOI: | 10.2217/imt-2018-0170 |
| Popis: | Aim: The aim of this study was to clarify whether there are more regulatory T (Treg) and regulatory B (Breg) cells, and higher levels of IL-10-related transcription factors in subcutaneous immunotherapy (SCIT)-treated pollinosis patients than in non-SCIT-treated patients. Methods: Japanese cedar pollinosis patients undergoing SCIT had received treatment for at least 2.8 years. Peripheral blood mononuclear cells were used for flow cytometer analyses and mRNA measurement. Results: The numbers of type 1 regulatory T (Tr1)-like cells and Breg cells, and expression of E4BP4 mRNA by peripheral blood mononuclear cells in SCIT-treated patients were higher than those in non-SCIT-treated patients. Conclusion: Tr1-like cells, Breg cells and E4BP4 may be involved in the effectiveness of SCIT. |
| Databáze: | OpenAIRE |
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