The type of the functional cardiovascular response to upright posture is associated with arterial stiffness: a cross-sectional study in 470 volunteers
| Autor: | Jukka Mustonen, Jenni Koskela, Jani Viitala, Marko Uitto, Jari Viik, Anna Tahvanainen, Tiit Kööbi, Mika Kähönen, Miia H. Leskinen, Antti Tikkakoski, Klaus Nordhausen, Ilkka Pörsti |
|---|---|
| Přispěvatelé: | Tampere University, Department of Clinical Physiology and Nuclear Medicine, School of Medicine, Institute of Biomedical Technology, Department of Electronics and Communications Engineering, Department of Internal medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Cardiac output Haemodynamic response 030204 cardiovascular system & hematology Cardiovascular System Body Mass Index 0302 clinical medicine Tilt-Table Test Cluster Analysis 030212 general & internal medicine Pulse wave velocity medicine.diagnostic_test Head-up tilt Age Factors Middle Aged Adaptation Physiological Arterial stiffness Impedance cardiography medicine.anatomical_structure Phenotype Cardiovascular Diseases Hypertension Cardiology Female Cardiology and Cardiovascular Medicine Research Article Adult medicine.medical_specialty Systemic vascular resistance Posture Heart rate Pulse Wave Analysis Autonomic Nervous System Cardiography Impedance 03 medical and health sciences Young Adult Vascular Stiffness Predictive Value of Tests Internal medicine medicine Humans Aged Plethysmography Whole Body business.industry Hemodynamics 217 Medical engineering medicine.disease Blood pressure Cross-Sectional Studies Vascular resistance Vascular Resistance business |
| Zdroj: | BMC Cardiovascular Disorders |
| Popis: | Background In a cross-sectional study we examined whether the haemodynamic response to upright posture could be divided into different functional phenotypes, and whether the observed phenotypes were associated with known determinants of cardiovascular risk. Methods Volunteers (n = 470) without medication with cardiovascular effects were examined using radial pulse wave analysis, whole-body impedance cardiography, and heart rate variability analysis. Based on the passive head-up tilt induced changes in systemic vascular resistance and cardiac output, the principal determinants of blood pressure, a cluster analysis was performed. Results The haemodynamic response could be clustered into 3 categories: upright increase in vascular resistance and decrease in cardiac output were greatest in the first (+45 % and -27 %, respectively), smallest in the second (+2 % and -2 %, respectively), and intermediate (+22 % and -13 %, respectively) in the third group. These groups were named as ‘constrictor’ (n = 109), ‘sustainer’ (n = 222), and ‘intermediate’ (n = 139) phenotypes, respectively. The sustainers were characterized by male predominance, higher body mass index, blood pressure, and also by higher pulse wave velocity, an index of large arterial stiffness, than the other groups (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|