Currently available intravenous immunoglobulin contains antibodies reacting against severe acute respiratory syndrome coronavirus 2 antigens

Autor: Carolina Romero, Rodrigo Gajardo, José-María Díez
Rok vydání: 2020
Předmět:
0301 basic medicine
Coronavirus disease 2019 (COVID-19)
Short Communication
viruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Pneumonia
Viral
Immunology
Enzyme-Linked Immunosorbent Assay
Cross Reactions
Antibodies
Viral
Virus
Betacoronavirus
03 medical and health sciences
0302 clinical medicine
Antigen
intravenous immunoglobulin
antibody content
Humans
Immunology and Allergy
Medicine
030212 general & internal medicine
Respiratory system
Antigens
Viral
Pandemics
biology
SARS-CoV-2
business.industry
Flebogamma DIF
fungi
virus diseases
COVID-19
Immunoglobulins
Intravenous
Flebogamma
body regions
030104 developmental biology
Severe acute respiratory syndrome-related coronavirus
Oncology
Middle East Respiratory Syndrome Coronavirus
biology.protein
Antibody
Coronavirus Infections
business
Zdroj: Immunotherapy
ISSN: 1750-7448
1750-743X
DOI: 10.2217/imt-2020-0095
Popis: Aim: There is a critical need for effective therapies that are immediately available to control the spread of COVID-19 disease. Material & methods: Gamunex®-C and Flebogamma® DIF (Grifols) intravenous immunoglobulin (IVIG) products were tested using ELISA techniques for antibodies against several antigens of human common betacoronaviruses that may crossreact with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Results: Both IVIGs showed consistent reactivity to components of the tested viruses. Positive crossreactivity was seen in SARS-CoV, middle east respiratory syndrome-CoV and SARS-CoV-2. For SARS-CoV-2, positive reactivity was observed at IVIG concentrations ranging from 100 μg/ml with Gamunex-C to 1 mg/ml with Flebogamma 5% DIF. Conclusion: Gamunex-C and Flebogamma DIF contain antibodies reacting against SARS-CoV-2 antigens. Studies to confirm the utility of IVIG preparations for COVID-19 management may be warranted.
Databáze: OpenAIRE
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