An autopsy case of primary mixed choriocarcinoma and mature teratoma located in the thymic region associated with elevated human chorionic gonadotropin levels and characteristic testicular changes
| Autor: | Yasuhiro Ohashi, Naoto Shimano, Takashi Yuri, Airo Tsubura, Reiko Tsukamoto, Katsuaki Miki |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Pleural effusion Autopsy Thymus Gland Biology Chorionic Gonadotropin Mediastinal Neoplasms Pathology and Forensic Medicine Human chorionic gonadotropin Fatal Outcome Internal medicine Testis medicine Humans Choriocarcinoma Molecular Biology Hyaline Leydig cell Teratoma General Medicine medicine.disease Sertoli cell Carcinoembryonic Antigen Endocrinology medicine.anatomical_structure alpha-Fetoproteins Luteinizing hormone |
| Zdroj: | Medical molecular morphology. 39(1) |
| ISSN: | 1860-1480 |
| Popis: | An autopsy case of a 19-year-old male Japanese student with a primary mixed choriocarcinoma and mature teratoma in the thymic region is reported. The patient died 7 days after he first noticed fever and dyspnea. On autopsy, an anterior mediastinal mass was found to be in contact with the thymic gland. The mass weighed 270 g and measured 12.5 cm × 10 cm × 5 cm. The left thoracic cavity contained 2200 ml bloody pleural effusion and 200 g coagula due to hemorrhage from the tumor. Metastasized choriocarcinoma was seen in both lungs and the liver. High serum levels of human chorionic gonadotropin (HCG, 1 634 000 mIU/ml) and a decreased weight of the testes (2.0 g each) with Leydig cell hyperplasia/hypertrophy and the seminiferous tubules with hyaline ghost tubules or Sertoli cell only tubules were seen; other male reproductive organs were histologically normal. Although the serum testosterone level was within the normal range (5.75 ng/ml), luteinizing hormone (LH, 0.1 mIU/ml) and follicle-stimulating hormone (FSH, 0.3 mIU/ml) levels were decreased. High serum levels of HCG and characteristic testicular changes are drscribed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink