tDCS and exercise improve anxiety-like behavior and locomotion in chronic pain rats via modulation of neurotrophins and inflammatory mediators
| Autor: | Wolnei Caumo, Paulo Roberto Stefani Sanches, Liciane Fernandes Medeiros, Helouise Richardt Medeiros, Iraci Lucena da Silva Torres, Dirson João Stein, Vanessa Silva de Souza, Stefania Giotti Cioato, Felipe Fregni, Bettega Costa Lopes |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Deltaproteobacteria
Male medicine.medical_treatment Anxiety Transcranial Direct Current Stimulation Elevated Plus Maze Test 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Neurochemical Physical Conditioning Animal medicine Animals Hippocampus (mythology) Rats Wistar 030304 developmental biology 0303 health sciences Transcranial direct-current stimulation biology Tumor Necrosis Factor-alpha business.industry Brain-Derived Neurotrophic Factor Chronic pain medicine.disease Combined Modality Therapy Interleukin-10 Rats Disease Models Animal Anesthesia Neuropathic pain biology.protein Sciatic nerve Chronic Pain medicine.symptom business Locomotion 030217 neurology & neurosurgery Neurotrophin |
| Zdroj: | Behavioural Brain Research. 404:113173 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2021.113173 |
| Popis: | Anxiety disorders cause distress and are commonly found to be comorbid with chronic pain. Both are difficult-to-treat conditions for which alternative treatment options are being pursued. This study aimed to evaluate the effects of transcranial direct current stimulation (tDCS), treadmill exercise, or both, on anxiety-like behavior and associated growth factors and inflammatory markers in the hippocampus and sciatic nerve of rats with neuropathic pain. Male Wistar rats (n = 216) were subjected to sham-surgery or sciatic nerve constriction for pain induction. Fourteen days following neuropathic pain establishment, either bimodal tDCS, treadmill exercise, or a combination of both was used for 20 min a day for 8 consecutive days. The elevated plus-maze test was used to assess anxiety-like behavior and locomotor activity during the early (24 h) or late (7 days) phase after the end of treatment. BDNF, TNF-ɑ, and IL-10 levels in the hippocampus, and BDNF, NGF, and IL-10 levels in the sciatic nerve were assessed 48 h or 7 days after the end of treatment. Rats from the pain groups developed an anxiety-like state. Both tDCS and treadmill exercise provided ethological and neurochemical alterations induced by pain in the early and/or late phase, and a modest synergic effect between tDCS and exercise was observed. These results indicate that non-invasive neuromodulatory approaches can attenuate both anxiety-like status and locomotor activity and alter the biochemical profile in the hippocampus and sciatic nerve of rats with neuropathic pain and that combined interventions may be considered as a treatment option. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect