Atrium and paroxetine-related severe hepatitis
| Autor: | V Pras, Bruno Devergie, A. Cazier, P Olympio, Ali Mofredj, Pierre Coutarel, Jean François Cadranel, A Gonzenbach, V Di Martino, M. Biour, C. Bachmeyer |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Gastroenterology Internal medicine Medicine Humans Drug Interactions Atrium (heart) Hepatitis Prothrombin time Chemotherapy medicine.diagnostic_test business.industry Jaundice medicine.disease Paroxetine Surgery Drug Combinations medicine.anatomical_structure Anti-Anxiety Agents Liver Liver biopsy Phenobarbital Barbiturates Histopathology Female medicine.symptom Chemical and Drug Induced Liver Injury business Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Journal of clinical gastroenterology. 28(1) |
| ISSN: | 0192-0790 |
| Popis: | Two cases of severe hepatitis in young women using Atrium and paroxetine are presented. Both patients presented jaundice, marked increase in aminotransferases activities, and pronounced prolongation in prothrombin time. In both cases, liver biopsy specimen examination revealed lesions compatible with drug-related injury. Other causes of hepatic injury were reasonably ruled out by complete careful screening. Outcome was marked by rapid complete recovery in one case and by slow recovery in the other. We suggest that simultaneous treatment with Atrium and paroxetine could increase each of these drugs' hepatotoxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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