Metabolic alterations and cardiovascular outcomes of cortisol excess
| Autor: | Giovanna Muscogiuri, Monica De Leo, Annamaria Colao, Alessia Cozzolino, Chiara Simeoli, Francesco Carlomagno, Davide Iacuaniello, Maria Cristina De Martino, Rosario Pivonello |
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| Přispěvatelé: | Pivonello, Rosario, DE MARTINO, MARIA CRISTINA, Iacuaniello, Davide, Simeoli, Chiara, Muscogiuri, Giovanna, Carlomagno, Francesco, DE LEO, Monica, Cozzolino, Alessia, Colao, Annamaria |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Diastole 030209 endocrinology & metabolism Disease Carbohydrate metabolism medicine.disease Left ventricular hypertrophy Cardiovascular Diseases Cushing Syndrome Humans Metabolic Syndrome 03 medical and health sciences Cushing syndrome 030104 developmental biology 0302 clinical medicine Endocrinology Internal medicine medicine Cardiology Adverse effect business Cardiovascular outcomes Dyslipidemia |
| Popis: | Cushing's syndrome (CS) is a severe chronic and systemic condition caused by endogenous or exogenous excess of glucocorticoids, associated with increased morbidity and mortality. Patients with active CS suffer from many metabolic alterations, including visceral obesity, systemic arterial hypertension, impairment of glucose metabolism and dyslipidemia. Additionally, in these patients several cardiovascular abnormalities, i.e. atherosclerosis, clotting disorders, left ventricular hypertrophy, concentric remodeling and diastolic dysfunction have been documented. These alterations, which persist even long after hypercortisolism remission, account for the increased cardiovascular risk and greatly contribute to the increased mortality observed in patients with CS. The current review aims to discuss the main adverse effects of CS on metabolism and cardiovascular risk, focusing on the active and remission phases of disease, and underlining the importance of long-term monitoring and treatment of these complications during active disease, as well as in the long-term follow-up after CS remission. |
| Databáze: | OpenAIRE |
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