Age and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition
| Autor: | Chaoban Wang, Chengjun Dai, Yonghai Zhou, Zishuo Liu, Xiaoou Shan, Fangqin Xia, Yiqi Mo |
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| Rok vydání: | 2021 |
| Předmět: |
genetic structures
Physiology body mass index Reference range Context (language use) Pediatrics RJ1-570 Age and gender chemistry.chemical_compound uric acid children Linear regression medicine Hyperuricemia Original Research business.industry nutritional and metabolic diseases reference interval medicine.disease Reference intervals chemistry Pediatrics Perinatology and Child Health Uric acid business Southeast China Body mass index |
| Zdroj: | Frontiers in Pediatrics, Vol 9 (2021) Frontiers in Pediatrics |
| ISSN: | 2296-2360 |
| DOI: | 10.3389/fped.2021.560720 |
| Popis: | Context: Hyperuricemia is defined when the plasma uric acid concentration is above 416 μmol/L (7 mg/dl) in male adults, or 357 μmol/L (6 mg/dl) in female adults. However, there are no explicit criteria yet for children.Objective: It is necessary to set up reference intervals for the uric acid level in different age groups among children.Materials and Methods: A total of 5,439 individuals (3,258 males, 2,181 females) were included in the final statistical analysis. Reference values of all age groups were determined by statistical descriptions. Multiple linear regression analysis was applied to determine the relationship between uric acid level, BMI, and age.Results: The level of uric acid increased with age. Gender differences in uric acid level occurred after the onset of puberty. Additionally, linear regression revealed a positive correlation between the uric acid level and BMI.Discussion and Conclusion: The reference range of the uric acid level in children is inconsistent with the previous viewpoint. Body mass index plays an important role in uric acid metabolism. |
| Databáze: | OpenAIRE |
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