Pharmacokinetics and tolerability of a new formulation of omeprazole in the horse
| Autor: | P. G. Predieri, Camillo Pieramati, Maria Chiara Marchesi, Simona Orvieto, Fabrizio Rueca, A. Di Salvo, M. Boveri, Francesco Zappulla, Sara Busechian, G. della Rocca |
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| Rok vydání: | 2016 |
| Předmět: |
EGUS
omeprazole pharmacokinetics 040301 veterinary sciences Cmax Pharmacology Group B omeprazole law.invention 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Randomized controlled trial law medicine Animals Horses Omeprazole General Veterinary business.industry Parallel study Horse 04 agricultural and veterinary sciences Anti-Ulcer Agents Tolerability Area Under Curve 030211 gastroenterology & hepatology EGUS business pharmacokinetics medicine.drug |
| Zdroj: | Journal of Veterinary Pharmacology and Therapeutics. 40:348-355 |
| ISSN: | 0140-7783 |
| DOI: | 10.1111/jvp.12371 |
| Popis: | A new formulation of omeprazole in gastro-resistant granules was tested with regard to its pharmacokinetics and tolerability. Twenty-four horses were randomly divided into three groups (8 horses/group) and treated, according a parallel study design, as follows: Group A untreated (control group), Group B received 4 mg/kg of omeprazole, and Group C received 12 mg/kg of omeprazole, both of which were treated orally once a day for 90 days. Blood samples, taken from Group B subjects during the 1st and the 29th day of treatment at pre-established time points, were used to determine the concentration-time curves of omeprazole. The treatments were found to be safe and well tolerated by the horses. The serum hematological and biochemical values were within reference ranges for the entire observational time. No accumulation of the drug was found after 29 days of treatment. Lower Cmax and AUCs were obtained at the 29th day of treatment. |
| Databáze: | OpenAIRE |
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