Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein

Autor: Ryan Vandrey, Sharon S Allen, Eric C. Donny, Neal L. Benowitz, Menglan Chen, Xianghua Luo, Jason D. Robinson, Mustafa al'Absi, Dorothy K. Hatsukami, Paul M. Cinciripini, Stephen S. Hecht, F. Joseph McClernon, Andrew A. Strasser, Rachel L Denlinger-Apte, Chap T. Le, Sharon E. Murphy, Joni Jensen, Chistopher Sipe, Steven G. Carmella
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Ionization
Physiology
Social Sciences
Urine
Toxicology
01 natural sciences
Biochemistry
Nicotine
chemistry.chemical_compound
Habits
0302 clinical medicine
Medicine and Health Sciences
Smoking Habits
Psychology
030212 general & internal medicine
Longitudinal Studies
Mercapturic acid
Acrolein
Randomized Controlled Trials as Topic
Multidisciplinary
Smokers
Chemical Reactions
Tobacco Products
Middle Aged
Glutathione
6. Clean water
3. Good health
Body Fluids
Urinary Biomarkers
Chemistry
Creatinine
Physical Sciences
Biomarker (medicine)
Medicine
Female
Acrylonitrile
Anatomy
medicine.drug
Research Article
Adult
Drug Research and Development
General Science & Technology
Science
Research and Analysis Methods
Hazardous Substances
Cigarette Smoking
03 medical and health sciences
MD Multidisciplinary
medicine
Humans
Clinical Trials
Pharmacology
Behavior
business.industry
010401 analytical chemistry
Biology and Life Sciences
Randomized Controlled Trials
0104 chemical sciences
Acetylcysteine
chemistry
Clinical Medicine
business
Peptides
Biomarkers
Toxicant
Zdroj: PLoS ONE, Vol 14, Iss 1, p e0210104 (2019)
PLoS ONE
Chen, Menglan; Carmella, Steven G; Sipe, Chistopher; Jensen, Joni; Luo, Xianghua; Le, Chap T; et al.(2019). Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein.. PloS one, 14(1), e0210104. doi: 10.1371/journal.pone.0210104. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/2034023n
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0210104.
Popis: The urinary metabolites cyanoethyl mercapturic acid (CEMA) and 3-hydroxypropyl mercapturic acid (3-HPMA) have been widely used as biomarkers of exposure to acrylonitrile and acrolein, respectively, but there are no published data on their consistency over time in the urine of cigarette smokers. We provided, free of charge over a 20 week period, Spectrum NRC600/601 research cigarettes to cigarette smokers in the control arm of a randomized clinical trial of the reduced nicotine cigarette. Urine samples were collected at weeks 4, 8, 12, 16, and 20 and analyzed for CEMA and 3-HPMA, and total nicotine equivalents (TNE) using validated methods. Creatinine-corrected intra-class correlation coefficients for CEMA, 3-HPMA, and TNE were 0.67, 0.46, and 0.68, respectively, indicating good longitudinal consistency for CEMA, while that of 3-HPMA was fair. A strong correlation between CEMA and TNE values was observed. These data support the use of CEMA as a reliable biomarker of tobacco smoke exposure. This is the first report of the longitudinal stability of the biomarkers of acrylonitrile and acrolein exposure in smokers. The data indicate that CEMA, the biomarker of acrylonitrile exposure, is consistent over time in cigarette smokers, supporting its use. While 3-HPMA levels were less stable over time, this biomarker is nevertheless a useful monitor of human acrolein exposure because of its specificity to this toxicant.
Databáze: OpenAIRE
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