Probing the multifactorial source of hand dysfunction in Friedreich ataxia
| Autor: | Geneieve Tai, Eppie M. Yiu, Sarah C Milne, Louise A. Corben, Brigitte Lynch, Martin B. Delatycki |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Weakness Contracture Ataxia Population Lower motor neuron Cerebral palsy 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Physiology (medical) Prevalence medicine Humans Spasticity education education.field_of_study Muscle Weakness business.industry Muscle weakness General Medicine Middle Aged Hand medicine.disease medicine.anatomical_structure Neurology Friedreich Ataxia Muscle Spasticity 030220 oncology & carcinogenesis Quality of Life Female Surgery Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Neuroscience. 64:71-76 |
| ISSN: | 0967-5868 |
| DOI: | 10.1016/j.jocn.2019.04.009 |
| Popis: | Friedreich ataxia (FRDA) has a significant effect on hand function which in turn, may compromise independence and quality of life. This study sought to identify the extent of muscle weakness, spasticity and changes in joint range in the hands of individuals with FRDA. We used the Modified Tardieu Scale (MTS), testing of muscle strength and goniometry to examine hand function in 19 individuals with FRDA. Relationships between clinical measures of disease severity, functional independence and measures of hand function were also explored. We found evidence for both upper and lower motor neuron impairment in this population. Thirteen (68.0%) participants had spasticity in the dominant wrist and finger flexors, and seven (36.8%) had contracture in at least one joint of either hand. Sixteen (84.3%) participants demonstrated weakness in the intrinsic musculature of the hands and the majority demonstrated some degree of hyperextension at the metacarpophalangeal joints of either hand. Significant correlations were found between functional independence capacity and clinical parameters, and components of spasticity and weakness in both the dominant and non-dominant hands. Moreover, spasticity and weakness in the dominant hand were shown to be significant predictors of reduced functional independence capacity. This study highlights for the first time the incidence of upper limb spasticity which, in combination with weakness and contracture, suggests a multifactorial source of hand dysfunction in people with FRDA. |
| Databáze: | OpenAIRE |
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