Impact of maternal BMI and gestational diabetes mellitus on maternal and cord blood metabolome: results from the PREOBE cohort study

Autor:	Berthold Koletzko, M.T. Segura, Engy Shokry, Mercedes G. Bermúdez, José Antonio García-Santos, Cristina Campoy, Linda Marchioro, Olaf Uhl
Rok vydání:	2018
Předmět:	Adult Male medicine.medical_specialty Offspring Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Fatty Acids Nonesterified Body Mass Index Cohort Studies 03 medical and health sciences 0302 clinical medicine Endocrinology NEFA Pregnancy Risk Factors Tandem Mass Spectrometry Internal medicine Diabetes mellitus Internal Medicine medicine Metabolome Humans Obesity Phospholipids business.industry Fatty Acids Infant Newborn nutritional and metabolic diseases General Medicine medicine.disease Fetal Blood Gestational diabetes Pregnancy Complications Diabetes Gestational Cord blood Prenatal Exposure Delayed Effects Female business Cohort study Chromatography Liquid
Zdroj:	Acta diabetologica. 56(4)
ISSN:	1432-5233
Popis:	Maternal obesity and gestational diabetes mellitus (GDM) were frequently reported to be risk factors for obesity and diabetes in offspring. Our goal was to study the impact of maternal prepregnancy BMI (pBMI) and GDM on both maternal and cord blood metabolic profiles. We used LC–MS/MS to measure 201 metabolites comprising phospholipids (PL), amino acids, non-esterified fatty acids (NEFA), organic acids, acyl carnitines (AC), and Krebs cycle metabolites in maternal plasma at delivery and cord plasma obtained from 325 PREOBE study participants. Several metabolites were associated with pBMI/GDM in both maternal and cord blood (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104b38941b9318d2c35771e9f518788a https://pubmed.ncbi.nlm.nih.gov/30725264 Zobrazit plný text záznamu Full text from SpringerLink