Superior and distinct antioxidant effects of selected estrogen metabolites on lipid peroxidation
| Autor: | M.T. Ravi Subbiah, William Abplanalp, Maoyun Tang, Stacey A. Ayres |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Antioxidant Hydroxyestrones Oxysterol Endocrinology Diabetes and Metabolism medicine.medical_treatment Lipoproteins VLDL Thiobarbituric Acid Reactive Substances Antioxidants Cell Line Lipid peroxidation chemistry.chemical_compound Endocrinology Internal medicine medicine TBARS Humans Equilin chemistry.chemical_classification Chemistry Cholesterol Macrophages Fatty Acids Fatty acid Lipoproteins LDL Sterols lipids (amino acids peptides and proteins) Lipid Peroxidation medicine.drug Lipoprotein |
| Zdroj: | Metabolism: clinical and experimental. 45(4) |
| ISSN: | 0026-0495 |
| Popis: | The effect of the estrogen metabolites, 4-hydroxyestrone and 17alpha-dihydroequilin (metabolites of estradiol-17beta and equilin, respectively), were examined for antioxidant effects on plasma and lipoprotein lipid peroxidation . Lipid peroxidation was evaluated by products of both fatty acid (thiobarbituric acid-reactive substances [TBARS]) and cholesterol (oxysterols) oxidation from lipoproteins or whole plasma. Although all estrogens significantly reduced lipid peroxidation, 4-hydroxyestrone was far more potent than either equilin or 17alpha-dihydroequilin in inhibiting TBARS formation in lipoproteins induced by Cu2+. Similar effects were also noted on TBARS formation in THP-l macrophages in culture. However, 17alpha-dihydroequilin (along with equilin) strongly inhibited oxysterol formation, whereas 4-hydroxyestrone was ineffective. These studies suggest that different estrogens might act preferentially on distinct lipid substrates in exhibiting antioxidant effects. |
| Databáze: | OpenAIRE |
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