Posterior Encephalopathy Subsequent to Cyclosporin A Presenting as Irreversible Abulia
| Autor: | Kozo Kurahashi, Hiroshi Midorikawa, Makoto Nishie, Yasuji Yoshida, Masaya Ogawa |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Pathology medicine.medical_specialty Encephalopathy Fluid-attenuated inversion recovery Brain Ischemia Central nervous system disease Pathogenesis Cyclosporin a Cortex (anatomy) Basal ganglia Internal Medicine medicine Humans Tomography Emission-Computed Single-Photon business.industry Toxic encephalopathy Brain General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Akinetic Mutism medicine.anatomical_structure Cyclosporine Neurotoxicity Syndromes business |
| Zdroj: | Internal Medicine. 42:750-755 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.42.750 |
| Popis: | A case of cyclosporin A (Cys A)-induced posterior encephalopathy developed into persistent abulia despite rapid and marked improvement of abnormal T2- and FLAIR MRI hyperintense regions. Diffusion-weighted MRI signal intensity was also high at the onset. This change is atypical in Cys A-induced encephalopathy and was thought to predict poor recovery from the encephalopathy. Persistent abulia was probably due to marked hypoperfusion in the whole cortex including bilateral frontal lobes and basal ganglia as detected by SPECT. Apart from the breakdown of the blood-brain barrier, direct toxicity of Cys A to the brain may play a role in the pathogenesis of chronic, irreversible encephalopathy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|