A Guide to Targeting the Endocannabinoid System in Drug Design
| Autor: | Adam Stasiulewicz, Monika Grudzień, Joanna I. Sulkowska, Katarzyna Znajdek, Tomasz Pawinski |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
Cannabinoid receptor media_common.quotation_subject Pain Review Anxiety Biology Neuroprotection Catalysis molecular target lcsh:Chemistry Inorganic Chemistry Seizures Humans FAAH endocannabinoid system Physical and Theoretical Chemistry Receptors Cannabinoid lcsh:QH301-705.5 Cannabinoid Receptor Antagonists Molecular Biology Spectroscopy media_common Cannabinoid Receptor Agonists Depression Human organism Organic Chemistry Neurogenesis ECS Neurodegenerative Diseases General Medicine CB1 Endocannabinoid system CB2 Computer Science Applications Crosstalk (biology) lcsh:Biology (General) lcsh:QD1-999 Drug Design MAGL Molecular targets Neuroscience |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 2778, p 2778 (2020) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms21082778 |
| Popis: | The endocannabinoid system (ECS) is one of the most crucial systems in the human organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of physiological processes, including nociception, mood regulation, cognitive functions, neurogenesis and neuroprotection, appetite, lipid metabolism, as well as cell growth and proliferation. Thus, ECS proteins, including cannabinoid receptors and their endogenous ligands’ synthesizing and degrading enzymes, are promising therapeutic targets. Their modulation has been employed in or extensively studied as a treatment of multiple diseases. However, due to a complex nature of ECS and its crosstalk with other biological systems, the development of novel drugs turned out to be a challenging task. In this review, we summarize potential therapeutic applications for ECS-targeting drugs, especially focusing on promising synthetic compounds and preclinical studies. We put emphasis on modulation of specific proteins of ECS in different pathophysiological areas. In addition, we stress possible difficulties and risks and highlight proposed solutions. By presenting this review, we point out information pivotal in the spotlight of ECS-targeting drug design, as well as provide an overview of the current state of knowledge on ECS-related pharmacodynamics and show possible directions for needed research. |
| Databáze: | OpenAIRE |
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