Outcome Prediction in Critically-Ill Patients with Venous Thromboembolism and/or Cancer Using Machine Learning Algorithms: External Validation and Comparison with Scoring Systems
| Autor: | Vasiliki Danilatou, Stylianos Nikolakakis, Despoina Antonakaki, Christos Tzagkarakis, Dimitrios Mavroidis, Theodoros Kostoulas, Sotirios Ioannidis |
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| Rok vydání: | 2022 |
| Předmět: |
Critical Illness
Organic Chemistry venous thromboembolism cancer mortality ICU interpretable machine learning General Medicine Venous Thromboembolism Catalysis Computer Science Applications Inorganic Chemistry Machine Learning Intensive Care Units ROC Curve Neoplasms Humans Physical and Theoretical Chemistry Molecular Biology Spectroscopy Algorithms Retrospective Studies |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7132 |
| ISSN: | 1422-0067 |
| Popis: | Intensive care unit (ICU) patients with venous thromboembolism (VTE) and/or cancer suffer from high mortality rates. Mortality prediction in the ICU has been a major medical challenge for which several scoring systems exist but lack in specificity. This study focuses on two target groups, namely patients with thrombosis or cancer. The main goal is to develop and validate interpretable machine learning (ML) models to predict early and late mortality, while exploiting all available data stored in the medical record. To this end, retrospective data from two freely accessible databases, MIMIC-III and eICU, were used. Well-established ML algorithms were implemented utilizing automated and purposely built ML frameworks for addressing class imbalance. Prediction of early mortality showed excellent performance in both disease categories, in terms of the area under the receiver operating characteristic curve (AUC–ROC): VTE-MIMIC-III 0.93, eICU 0.87, cancer-MIMIC-III 0.94. On the other hand, late mortality prediction showed lower performance, i.e., AUC–ROC: VTE 0.82, cancer 0.74–0.88. The predictive model of early mortality developed from 1651 VTE patients (MIMIC-III) ended up with a signature of 35 features and was externally validated in 2659 patients from the eICU dataset. Our model outperformed traditional scoring systems in predicting early as well as late mortality. Novel biomarkers, such as red cell distribution width, were identified. |
| Databáze: | OpenAIRE |
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