3,5,6,7,8,3′,4′-Heptamethoxyflavone, a Citrus Polymethoxylated Flavone, Attenuates Inflammation in the Mouse Hippocampus
| Autor: | Yoshiaki Amakura, Morio Yoshimura, Yoshiko Furukawa, Mitsunari Nakajima, Yuichi Tsumura, Takashi Yoshida, Kazuhiro Miyoshi, Satoshi Okuyama |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
3
5 6 7 8 3′ 4′-heptamethoxyflavone Lipopolysaccharide hippocampus microglia Inflammation Pharmacology Bioinformatics Flavones lcsh:RC321-571 chemistry.chemical_compound In vivo medicine Hippocampus (mythology) lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Neuroinflammation Mouse Hippocampus chemistry.chemical_classification Microglia business.industry Communication General Neuroscience anti-inflammation medicine.anatomical_structure chemistry IL-1β medicine.symptom business |
| Zdroj: | Brain Sciences, Vol 5, Iss 2, Pp 118-129 (2015) Brain Sciences |
| ISSN: | 2076-3425 |
| DOI: | 10.3390/brainsci5020118 |
| Popis: | Citrus polymethoxylated flavones (PMFs) have recently been shown to suppress inflammation in peripheral tissues. In the present study, we investigated the effects of 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF), one of the PMFs, on inflammation in the brain in vivo using mice injected intrahippocampally with lipopolysaccharide (LPS). We demonstrated that subcutaneously injected HMF suppressed: (1) LPS-induced losses in body weight; (2) LPS-induced microglial activation in the hippocampus; and (3) LPS-induced interleukin-1β mRNA expression in the hippocampus. These results suggest that HMF has the ability to reduce neuroinflammation in the brain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|