Mechanism of the ventilatory response to acute blood loss
| Autor: | D. Varga, D.J. Gillett, I.R. Neering, D.F.J. Halmagyi |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Cardiac Catheterization Pulmonary Circulation Physiology Hemorrhage Biology Shock Hemorrhagic chemistry.chemical_compound Cerebrospinal fluid Catecholamines Dogs Internal medicine Hyperventilation medicine Animals Lung Sheep Central chemoreceptors Respiration Carbon Dioxide Hydrogen-Ion Concentration Lactic acid Oxygen Bicarbonates Endocrinology medicine.anatomical_structure chemistry Control of respiration Anesthesia Shock (circulatory) Catecholamine Lactates medicine.symptom Acidosis medicine.drug |
| Zdroj: | Respiration physiology. 4(2) |
| ISSN: | 0034-5687 |
| Popis: | In unanaesthetised sheep haemorrhagic hypotension was followed by increased total and alveolar ventilation and a marked rise in the ventilation-perfusion ratio of the lung. In unanaesthetised dogs the response mainly consisted of a rise in the ventilation-perfusion ratio only. In both species, the ventilatory response to haemorrhage was unrelated to arterial H+ activity and related to metabolic rate and lactic acid plasma level. It is suggested that hyperventilation in shock is secondary to increased endogenous catecholamine secretion. Catecholamines increase metabolic rate and lactic acid formation and an increment in intracellular lactic acid concentration could account for enhanced activity of the peripheral and central chemoreceptors. |
| Databáze: | OpenAIRE |
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