Physicochemical compatibility studies of triclosan and flurbiprofen with excipients of pharmaceutical formulation using binary, ternary, and multi-combination approach
| Autor: | Nuhu Tanko, Nura Muhammad Umar, Sirajo Abubakar Zauro, Momoh A. Mumuni, Siok-Yee Chan, Abdulmalik Aminu, Nafiu Aminu, Seok-Ming Toh |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Scanning electron microscope Flurbiprofen 02 engineering and technology RM1-950 Pharmaceutical formulation 01 natural sciences Chitosan chemistry.chemical_compound Differential scanning calorimetry Pharmacy and materia medica medicine Fourier transform infrared spectroscopy Poly-ε-caprolactone 021001 nanoscience & nanotechnology Triclosan 010406 physical chemistry 0104 chemical sciences RS1-441 chemistry Drug-Excipient Compatibility studies Therapeutics. Pharmacology 0210 nano-technology Ternary operation Powder diffraction medicine.drug Nuclear chemistry |
| Zdroj: | Future Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-16 (2021) |
| ISSN: | 2314-7253 |
| Popis: | Background The aim of the study was to evaluate the suitability of triclosan (TCS) and flurbiprofen (FLB) with poly-ε-caprolactone (PCL), chitosan (CS), and Kolliphor® P188 (KP) for possible application in the design of nano-formulations. Results Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and scanning electron microscopy (SEM) revealed the physical characteristics of the various sample compositions without any apparent interaction. The Fourier transform infrared spectroscopy (FTIR)’s spectra of the physical mixtures showed their characteristic absorption bands with broadening and overlapping of bands in some instances, but no appearance of new bands was observed. Conclusion The study revealed the physical form stability of the evaluated components after the storage period and lack of definite pharmaceutical incompatibility between them. Thus, the selected drugs and excipients could be used for the development of pharmaceutical nano-formulations. |
| Databáze: | OpenAIRE |
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