Randomized Controlled Trial of High‐Volume Energy Drink Versus Caffeine Consumption on ECG and Hemodynamic Parameters

Autor: Andrew Occiano, Sachin A. Shah, Carolyn S Lacey, Mark W Kolasa, Melenie Aaron, Emily A Fletcher
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_specialty
Time Factors
Adolescent
electrocardiography
Hemodynamics
Blood Pressure
Arrhythmias
030204 cardiovascular system & hematology
arrhythmia
Risk Assessment
law.invention
Young Adult
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Randomized controlled trial
energy drink
Heart Conduction System
Heart Rate
Predictive Value of Tests
law
Caffeine
Internal medicine
medicine
Energy Drinks
Humans
Arrhythmia and Electrophysiology
030212 general & internal medicine
Original Research
Diet and Nutrition
Cross-Over Studies
medicine.diagnostic_test
business.industry
Arrhythmias
Cardiac
electrophysiology
Surgery
Blood pressure
Volume (thermodynamics)
Caffeine consumption
Hypertension
Cardiology
Central Nervous System Stimulants
Female
Cardiology and Cardiovascular Medicine
business
Electrocardiography
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
ISSN: 2047-9980
DOI: 10.1161/jaha.116.004448
Popis: Background Caffeine in doses BP ) effects of high‐volume energy drink consumption compared with caffeine alone. Methods and Results This was a randomized, double‐blind, controlled, crossover study in 18 young, healthy volunteers. Participants consumed either 946 mL (32 ounces) of energy drink or caffeinated control drink, both of which contained 320 mg of caffeine, separated by a 6‐day washout period. ECG , peripheral BP , and central BP measurements were obtained at baseline and 1, 2, 4, 6, and 24 hours post study drink consumption. The time‐matched, baseline‐adjusted changes were compared. The change in corrected QT interval from baseline in the energy drink arm was significantly higher than the caffeine arm at 2 hours (0.44±18.4 ms versus −10.4±14.8 ms, respectively; P =0.02). The QT c changes were not different at other time points. While both the energy drink and caffeine arms raised systolic BP in a similar fashion initially, the systolic BP was significantly higher at 6 hours when compared with the caffeine arm (4.72±4.67 mm Hg versus 0.83±6.09 mm Hg, respectively; P =0.01). Heart rate, diastolic BP , central systolic BP , and central diastolic BP showed no evidence of a difference between groups at any time point. Post energy drink, augmentation index was lower at 6 hours. Conclusions The corrected QT interval and systolic BP were significantly higher post high‐volume energy drink consumption when compared with caffeine alone. Larger clinical trials validating these findings and evaluation of noncaffeine ingredients within energy drinks are warranted. Clinical Trial Registration URL : http://www.clinicaltrials.gov . Unique identifier: NCT 02023723.
Databáze: OpenAIRE
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