Correlation between circulating blood and microenvironment T lymphocytes in diffuse large B-cell lymphomas
| Autor: | Eugenio Maiorano, Giuseppe Ingravallo, Roberto Tamma, Giorgina Specchia, Domenico Ribatti, Tommasina Perrone, Anna Mestice, Filomena Emanuela Laddaga, Francesco Gaudio |
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| Rok vydání: | 2020 |
| Předmět: |
CD3
Lymphocyte Monocytes Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Immune system medicine Tumor Microenvironment Humans Lymphocyte Count Lymphocytes B cell biology Antitumor immunity Chemistry Monocyte General Medicine medicine.disease Prognosis Lymphoma medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research biology.protein Lymphoma Large B-Cell Diffuse Infiltration (medical) 030215 immunology |
| Zdroj: | Journal of clinical pathology. 75(7) |
| ISSN: | 1472-4146 |
| Popis: | AimsDiffuse large B-cell lymphoma (DLBCL) is characterised by marked clinical and biological heterogeneity, attributable to the tumour cells and their microenvironment.MethodsIn this study, we investigated circulating subsets of blood lymphocytes and monocytes and their relationship with T cells in the tumour microenvironment (TME) in chemoresistant and chemosensitive patients with DLBCL.ResultsThe study showed that (1) absolute lymphocyte count (ALC) and CD3+ and CD4+ cells were reduced in chemoresistant patients compared with chemosensitive patients; (2) lymphocyte:monocyte ratio (LMR) showed a positive correlation with peripheral blood CD3+ and CD4+ cells; (3) ALC, LMR, peripheral blood CD3+ and CD4+ cells showed a positive correlation with T cells in the TME.ConclusionsOverall, these data suggest that DLBCL with high TME T cells display a pre-existing antitumour immune response. In the rituximab-containing regimen, TME T cells are stimulated further to participate in the immune response against lymphoma cells. In contrast, DLBCL lymphomas with low T-cell infiltration reflect the absence of a pre-existing antitumour immunity and have a lower likelihood of obtaining an optimal response to therapy. |
| Databáze: | OpenAIRE |
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