Advances and considerations in AD tau-targeted immunotherapy
| Autor: | Alice Bittar, Rakez Kayed, Nemil Bhatt |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
extracellular tau Disease onset Amyloid Beta immunotherapy Amyloid beta medicine.medical_treatment Tau protein tau Proteins Disease Article Targeted immunotherapy lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Alzheimer Disease medicine Animals Humans Disease process lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Tau-targeted immunotherapy Clinical Trials as Topic biology business.industry Early disease Brain Immunotherapy Alzheimer's disease 3. Good health 030104 developmental biology Neurology Alzheimer’s disease clinical trials biology.protein Tau business Neuroscience Alzheimer’s disease 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Neurobiology of disease Neurobiology of Disease, Vol 134, Iss, Pp-(2020) |
| ISSN: | 1095-953X |
| Popis: | The multifactorial and complex nature of Alzheimer’s disease (AD) has made it difficult to identify therapeutic targets that are causally involved in the disease process. However, accumulating evidence from experimental and clinical studies that investigate the early disease process point towards the required role of tau in AD etiology. Importantly, a large number of studies investigate and characterize the plethora of pathological forms of tau protein involved in disease onset and propagation. Immunotherapy is one of the most clinical approaches anticipated to make a difference in the field of AD therapeutics. Tau –targeted immunotherapy is the new direction after the failure of amyloid beta (Aß)-targeted immunotherapy and the growing number of studies that highlight the Aß-independent disease process. It is now well established that immunotherapy alone will most likely be insufficient as a monotherapy. Therefore, this review discusses updates on tau-targeted immunotherapy studies, AD-relevant tau species, updates on promising biomarkers and a prospect on combination therapies to surround the disease propagation in an efficient and timely manner. Graphical Abstract |
| Databáze: | OpenAIRE |
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