Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers
| Autor: | Hiroaki Kumada, Yoshitaka Matsumoto, Hirotaka Sugawara, Guillaume Vares, Vincent Jallet, Cédric Rentier, Yoshio Hayashi, Toshio Sasaki, Kentaro Takayama |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
inorganic chemicals
Gadolinium medicine.medical_treatment Biomedical Engineering Chondrosarcoma Pharmaceutical Science Medicine (miscellaneous) chemistry.chemical_element Bioengineering Boron Neutron Capture Therapy 02 engineering and technology Cell-Penetrating Peptides Radiation Tolerance Metastasis 03 medical and health sciences Drug Delivery Systems Cancer stem cell In vivo Cell Line Tumor medicine Humans General Materials Science 030304 developmental biology 0303 health sciences Cell Death Mesoporous silica 021001 nanoscience & nanotechnology medicine.disease Silicon Dioxide Radiation therapy Neutron capture chemistry Cancer research Molecular Medicine Nanoparticles 0210 nano-technology DNA Damage |
| Zdroj: | Nanomedicine : nanotechnology, biology, and medicine. 27 |
| ISSN: | 1549-9642 |
| Popis: | Treatment resistance, relapse and metastasis remain critical issues in some challenging cancers, such as chondrosarcomas. Boron-neutron Capture Therapy (BNCT) is a targeted radiation therapy modality that relies on the ability of boron atoms to capture low energy neutrons, yielding high linear energy transfer alpha particles. We have developed an innovative boron-delivery system for BNCT, composed of multifunctional fluorescent mesoporous silica nanoparticles (B-MSNs), grafted with an activatable cell penetrating peptide (ACPP) for improved penetration in tumors and with Gadolinium for magnetic resonance imaging (MRI)in vivo. Chondrosarcoma cells were exposedin vitroto an epithermal neutron beam after B-MSNs administration. BNCT beam exposure successfully induced DNA damage and cell death, including in radio-resistant ALDH+ cancer stem cells (CSCs), suggesting that BNCT using this system might be a suitable treatment modality for chondrosarcoma or other hard-to-treat cancers. |
| Databáze: | OpenAIRE |
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