Large-scale oscillatory calcium waves in the immature cortex
Autor: | Olga Garaschuk, Jens Eilers, Arthur Konnerth, Jennifer Linn |
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Rok vydání: | 2000 |
Předmět: |
Posterior parietal cortex
AMPA receptor Tetrodotoxin Biology In Vitro Techniques Bicuculline Hippocampus Receptors N-Methyl-D-Aspartate Membrane Potentials GABA Antagonists Receptors GABA Giant depolarizing potentials Cortex (anatomy) medicine Animals Calcium Signaling Receptors AMPA Rats Wistar Receptor gamma-Aminobutyric Acid 6-Cyano-7-nitroquinoxaline-2 3-dione Cerebral Cortex Neurons Photons GABAA receptor General Neuroscience Electric Conductivity Depolarization Rats medicine.anatomical_structure Animals Newborn NMDA receptor Calcium Nerve Net Neuroscience Excitatory Amino Acid Antagonists |
Zdroj: | Nature neuroscience. 3(5) |
ISSN: | 1097-6256 |
Popis: | Two-photon imaging of large neuronal networks in cortical slices of newborn rats revealed synchronized oscillations in intracellular Ca2+ concentration. These spontaneous Ca2+ waves usually started in the posterior cortex and propagated slowly (2.1 mm per second) toward its anterior end. Ca2+ waves were associated with field-potential changes and required activation of AMPA and NMDA receptors. Although GABAA receptors were not involved in wave initiation, the developmental transition of GABAergic transmission from depolarizing to hyperpolarizing (around postnatal day 7) stopped the oscillatory activity. Thus we identified a type of large-scale Ca2+ wave that may regulate long-distance wiring in the immature cortex. |
Databáze: | OpenAIRE |
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