Fecal calprotectin in very low birth weight infants
| Autor: | Susan K Bunn, Stina Josefsson, Magnus Domellöf |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Meconium medicine.medical_specialty Gastrointestinal Diseases Gastroenterology Feces fluids and secretions Enterocolitis Necrotizing Internal medicine medicine Humans Infant Very Low Birth Weight business.industry Infant Newborn medicine.disease Infant newborn Low birth weight Recien nacido Pediatrics Perinatology and Child Health Immunology Necrotizing enterocolitis Female Calprotectin medicine.symptom business Leukocyte L1 Antigen Complex Biomarkers |
| Zdroj: | Journal of pediatric gastroenterology and nutrition. 44(4) |
| ISSN: | 1536-4801 |
| Popis: | To measure concentrations of fecal calprotectin (f-calprotectin) in infants with very low birth weight (VLBW;1500 g) longitudinally and to describe changes in f-calprotectin in infants who develop severe abdominal disease.The study included 59 VLBW infants. Seven patients (disease group) developed severe abdominal disease defined as necrotizing enterocolitis (NEC) or a condition leading to laparotomy. The remainder (n = 52) were considered reference infants and had a mean (+/-SD) gestational age of 27.2 +/- 2.6 weeks and a birth weight of 939 +/- 273 g. F-calprotectin was analyzed in meconium and weekly during postnatal weeks 1 to 8. In disease cases, more frequent samples were analyzed around the time of abdominal disease diagnosis.In reference infants the median (range) f-calprotectin level in meconium was 332 (12-9386) microg/g and correlated negatively to Apgar score. F-calprotectin in postmeconium samples was 253 (9-1867) microg/g and correlated positively to delivery by cesarean section, postnatal age, and volume of enteral feeds, and negatively to treatment with antibiotics and corticosteroids. In reference infants no postmeconium sample had f-calprotectin levels2000 microg/g. In disease cases f-calprotectin was increased to2000 microg/g in 3 cases of NEC and 1 case of covered perforation with microscopic bowel inflammation. In 1 case of NEC without microscopic bowel inflammation and 2 cases of focal intestinal perforation, f-calprotectin levels never exceeded 2000 microg/g.F-calprotectin concentrations in VLBW infants are similar to previously reported levels in healthy term and moderately preterm infants. An f-calprotectin level2000 microg/g is a useful but not an early marker of NEC and other severe intestinal inflammatory conditions in VLBW infants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text