Expression of Pattern Recognition Receptors by Nociceptive Metasympathetic Neurons
| Autor: | Nozdrachev Ad, L. V. Filippova, F. S. Malyshev, O. N. Platonova, E. Yu. Bystrova |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Colon TRPV1 Myenteric Plexus TRPV Cation Channels Statistics Nonparametric General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley medicine Animals Receptor Plexus Microscopy Confocal Innate immune system Chemistry musculoskeletal neural and ocular physiology Pattern recognition receptor Nociceptors Submucous Plexus General Medicine Immunohistochemistry Rats Cell biology Toll-Like Receptor 4 medicine.anatomical_structure nervous system Receptors Pattern Recognition TLR4 lipids (amino acids peptides and proteins) Neuron |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 159:248-252 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-015-2934-5 |
| Popis: | Immunohistochemical assay with double label and confocal laser scanning microscopy showed that innate immunity receptor TLR4 is expressed predominantly in neurons of the intestinal Auerbach (myenteric) plexus, while vanilloid nociceptive receptor TRPV1 is expressed by neurons of Meissner (submucous) plexus. Immunohistochemical analysis with triple labeling revealed coexpression of TLR4 and TRPV1 in enteric neurons of rat colon. The results attest to a possibility of functional interaction between Toll-like and vanilloid receptors in the neuron level. |
| Databáze: | OpenAIRE |
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