Compositional and functional alterations of gut microbiota in patients with stroke
| Autor: | Qiong-Qiong Lin, Ke-Ke Jin, Lianyan Wei, Lin-Bo Yuan, Li Chen, Kai-Cheng Wang, Dongjuan Xu, Yunyun Xu, Hong-Fei Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Trimethylamine N-oxide Gut flora digestive system Gastroenterology chemistry.chemical_compound Internal medicine Gut bacteria medicine Humans Choline In patient Stroke Nutrition and Dietetics biology business.industry biology.organism_classification medicine.disease Gastrointestinal Microbiome chemistry Case-Control Studies Potential biomarkers Plaque area Cardiology and Cardiovascular Medicine business |
| Zdroj: | Nutrition, Metabolism and Cardiovascular Diseases. 31:3434-3448 |
| ISSN: | 0939-4753 |
| DOI: | 10.1016/j.numecd.2021.08.045 |
| Popis: | BACKGROUND AND AIMS There is accumulating evidence that gut microbiota plays a key role in cardiovascular diseases. Gut bacteria can transform dietary choline, l-carnitine, and trimethylamine N-oxide (TMAO) into trimethylamine, which can be oxidized into TMAO again in the liver. However, the alterations of the gut microbiota in large artery atherosclerotic (LAA) stroke and cardioembolic (CE) stroke have been less studied. METHODS AND RESULTS We performed a case-control study in patients with LAA and CE types of strokes. We profiled the gut microbiome using Illumina sequencing of the 16S ribosomal RNA gene (V4-V5 regions), and TMAO was determined via liquid chromatography-tandem mass spectrometry. Our results showed that the TMAO levels in the plasma of patients with LAA and CE strokes were significantly higher than those in controls (LAA stroke, 2931 ± 456.4 ng/mL; CE stroke, 4220 ± 577.6 ng/mL; healthy control, 1663 ± 117.8 ng/mL; adjusted p |
| Databáze: | OpenAIRE |
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