The role of HINT1 in methamphetamine-induced behavioral sensitization

Autor:	Gang Lei, Peng Liu, Liu Yang, Zheng Chu, Yonghui Dang, Li-Sha Deng, Jun-Liang He
Rok vydání:	2020
Předmět:	Male medicine.medical_specialty media_common.quotation_subject Hippocampus Prefrontal Cortex Nerve Tissue Proteins Nucleus accumbens Nucleus Accumbens Methamphetamine 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Internal medicine medicine Distribution (pharmacology) Animals Prefrontal cortex media_common Pharmacology Mice Knockout business.industry Addiction Meth medicine.disease 030227 psychiatry Behavior Addictive Mice Inbred C57BL Endocrinology chemistry Central Nervous System Stimulants Addictive behavior business 030217 neurology & neurosurgery Locomotion medicine.drug
Zdroj:	Psychopharmacology. 237(8)
ISSN:	1432-2072
Popis:	Drug addiction is a chronically relapsing disorder in humans yet the underlying mechanism remained unclear. Recent studies suggested that histidine triad nucleotide binding protein1 (HINT1) may play significant roles in diverse neuropsychiatric diseases including drug addiction. In the current study, we used different batches of mice to establish different stages of methamphetamine (METH)-induced behavioral sensitization (BS) to explore the dynamic changes throughout the process of addiction in different brain regions, including the prefrontal cortex (PFC), nucleus accumbens (NAc), caudate putamen (CPu), and hippocampus (Hip). In addition, we used HINT1 knockout (KO) mice to investigate the effect of HINT1 protein deletion on METH-induced BS. We found that in PFC of the METH group mice, the HINT1 expression level initially increased after development phase, and then dropped to the normal level during expression phase. However, there was no statistical difference in the HINT1 expression level in the other three encephalic regions (NAc, CPu, and Hip). The absence of HINT1 could promote METH-mediated addictive behavior to a certain extent, while the significant difference between genotypes only occurred in the development phase. Using the new technique, hip fractures were correctly predicted in 78% of cases compared with 36% when using the T-score. The accuracy of the prediction was not greatly reduced when using SSM and SAM (78% and 74% correct, respectively). Various geometric and BMD distribution traits were identified in the fractured and non-fractured groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7a0898d09b97a9f76a361e45685e40 https://pubmed.ncbi.nlm.nih.gov/32430517 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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