New cycloalkyl[b]thiophenylnicotinamide-based α-glucosidase inhibitors as promising anti-diabetic agents: Synthesis, in silico study, in vitro and in vivo evaluations

Autor:	Kai-Ming, Wang, Yong-Xi, Ge, Jie, Zhang, Yi-Tong, Chen, Nai-Yu, Zhang, Jin-Song, Gu, Lei, Fang, Xin-Lei, Zhang, Juan, Zhang, Cheng-Shi, Jiang
Rok vydání:	2023
Předmět:	Organic Chemistry Clinical Biochemistry Pharmaceutical Science alpha-Glucosidases Biochemistry Rats Molecular Docking Simulation Drug Discovery Animals Hypoglycemic Agents Molecular Medicine Glycoside Hydrolase Inhibitors Acarbose Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 79:129069
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2022.129069
Popis:	In the present study, a series of cycloalkyl[b]thiophenylnicotinamide derivatives against α-glucosidase were synthesized, and evaluated for their in vitro and in vivo anti-diabetic potential. Most of the synthetic analogues exhibited superior α-glucosidase inhibitory effects than the standard drug acarbose (IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5cebe94baeceb81224f29020eb42e1 https://doi.org/10.1016/j.bmcl.2022.129069 Zobrazit plný text záznamu Full Text from ScienceDirect