Role of TGF-β signaling in the mechanisms of tamoxifen resistance
| Autor: | Polina Gervas, Tatyana Dronova, Daiana Erdyneeva, Nadejda Cherdyntseva, Nataliya Babyshkina |
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| Rok vydání: | 2021 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Immunology Estrogen receptor Breast Neoplasms Drug resistance General Biochemistry Genetics and Molecular Biology Transforming Growth Factor beta medicine Humans Immunology and Allergy skin and connective tissue diseases biology Estrogen Antagonists Transforming growth factor beta Antiestrogen Tamoxifen Drug Resistance Neoplasm Cancer research biology.protein Female Signal transduction Stem cell hormones hormone substitutes and hormone antagonists Signal Transduction medicine.drug Transforming growth factor |
| Zdroj: | Cytokine & Growth Factor Reviews. 62:62-69 |
| ISSN: | 1359-6101 |
| DOI: | 10.1016/j.cytogfr.2021.09.005 |
| Popis: | The transforming growth factor beta (TGF-β) signaling pathway plays complex role in the regulation of cell proliferation, apoptosis and differentiation in breast cancer. TGF-β activation can lead to multiple cellular responses mediating the drug resistance evolution, including the resistance to antiestrogens. Tamoxifen is the most commonly prescribed antiestrogen that functionally involved in regulation of TGF-β activity. In this review, we focus on the role of TGF-β signaling in the mechanisms of tamoxifen resistance, including its interaction with estrogen receptors alfa (ERα) pathway and breast cancer stem cells (BCSCs). We summarize the current reported data regarding TGF-β signaling components as markers of tamoxifen resistance and review current approaches to overcoming tamoxifen resistance based on studies of TGF-β signaling. |
| Databáze: | OpenAIRE |
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