A population-based study on the prognostic impact of primary tumor sidedness in patients with peritoneal metastases from colon cancer

Autor: Cornelis Verhoef, Jacobus W. A. Burger, Niels F. M. Kok, Philip H. de Reuver, Koen P. Rovers, Amanda C.R.K. Bos, Ignace H. J. T. de Hingh, Johannes H. W. de Wilt, Nadine L. de Boer, Eva V. E. Madsen, Alexandra R. M. Brandt-Kerkhof
Přispěvatelé: Surgery
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Oncology
Cancer Research
Colorectal cancer
primary tumor sidedness
Cecal Neoplasms
Hyperthermic Intraperitoneal Chemotherapy
Kaplan-Meier Estimate
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]
0302 clinical medicine
Peritoneal Neoplasms
Netherlands
Original Research
education.field_of_study
Medical record
Palliative Care
Cytoreduction Surgical Procedures
Middle Aged
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Primary tumor
Colon cancer
Colon
Descending
peritoneal metastases
030220 oncology & carcinogenesis
Colonic Neoplasms
Female
Hyperthermic intraperitoneal chemotherapy
Colon
Transverse
Cohort study
medicine.medical_specialty
Population
lcsh:RC254-282
Colon
Ascending
03 medical and health sciences
SDG 3 - Good Health and Well-being
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
In patient
education
Aged
Retrospective Studies
business.industry
Clinical Cancer Research
medicine.disease
Survival Analysis
Cancer registry
Sigmoid Neoplasms
030104 developmental biology
Multivariate Analysis
business
Zdroj: Cancer Medicine, Vol 9, Iss 16, Pp 5851-5859 (2020)
Cancer Medicine, 9, 5851-5859
Cancer Medicine, 9(16), 5851-5859. John Wiley & Sons Ltd.
Cancer Medicine, 9, 16, pp. 5851-5859
Cancer Medicine
ISSN: 2045-7634
Popis: Primary tumor location is an established prognostic factor in patients with (metastatic) colon cancer. Colon tumors can be divided into left‐sided and right‐sided tumors. The aim of this study was to determine the impact of primary tumor location on treatment and overall survival (OS) in patients with peritoneal metastases (PM) from colon cancer. This study is a retrospective, population‐based cohort study. Records of patients diagnosed with colon cancer and synchronous PM, from 1995 through 2016, were retrieved from the Netherlands Cancer Registry (NCR). Data on diagnosis, staging, and treatment were extracted from the medical records by specifically trained NCR personnel. Information on survival status was updated annually using a computerized link with the national civil registry. In total, 7930 patients were included in this study; 4555 (57.4%) had a right‐sided and 3375 (42.6%) had a left‐sided primary tumor. In multivariable analysis right‐sided primary tumor was associated with worse OS (HR: 1.11, 95% CI 1.03‐1.19, P = .007). Of all patients diagnosed with PM, 564 (7.1%) underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC). Patients with left‐sided primary tumors were more often candidates for CRS‐HIPEC (6.5% vs. 8.0%, P = .008). OS of patients with right‐ and left‐sided tumors who underwent CRS‐HIPEC did not significantly differ. In conclusion, primary right‐sided colon cancer was an independent prognostic factor for decreased OS in patients diagnosed with synchronous PM. In patients treated with CRS‐HIPEC location of the primary tumor did not influence survival.
Primary tumor location is an established prognostic factor for patients with colon cancer. Little is known about the impact of tumor location on the outcomes of patients with peritoneal metastases. In a population‐based study in the Netherlands, primary right‐sided colon cancer was an independent prognostic factor for decreased survival in patients with synchronous peritoneal metastases. In patients with synchronous peritoneal metastases treated with CRS‐HIPEC, location of the primary tumor did not influence survival.
Databáze: OpenAIRE
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