A Meta-Analysis of Association between Remdesivir and Mortality among Critically-Ill COVID-19 Patients
| Autor: | Greeshma Erasani, Syed Adeel Hassan, Dario Missael Rocha-Castellanos, Sai Kumar Reddy Pasya, Alfonso Lopez-Mendez, Sham Kumar, Sarah Abdul Razzack, Aminah Abdul Razzack |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) business.industry Mortality rate Scopus Remdesivir COVID-19 Odds ratio Antiviral therapy Confidence interval Cochran–Mantel–Haenszel statistics Critical care Infectious Diseases Systematic review Meta-analysis Emergency medicine Medicine Pharmacology (medical) Original Article business |
| Zdroj: | Infection & Chemotherapy |
| ISSN: | 2092-6448 2093-2340 |
| Popis: | BACKGROUND: The World Health Organization guidelines did not make a recommendation on use of remdesivir based on disease severity. Little is known regarding effectiveness of remdesivir in critically ill coronavirus disease 2019 (COVID-19) patients. This has led to a state of dilemma for doctors leaving them skeptical of whether they should continue to recommend the drug or not. MATERIALS AND METHODS: A systematic search adhering to preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines was conducted from inception until February 20, 2020. Electronic bibliographic databases (PubMed, Cochrane database, Scopus, Embase) were included. Using dichotomous data for select values, the unadjusted odds ratios (ORs) were calculated applying Mantel Haenszel (M-H) using random-effects model. The primary outcome of interest was all-cause mortality in ventilated and non-ventilated patients. RESULTS: The Remdesivir arm was associated with similar rates of 28-day all-cause mortality (OR: 0.93, 95% confidence interval [CI]: 0.80 - 1.08; P = 0.33). Remdesivir was not found to be favorable for ventilated patients. Non ventilated COVID-19 patients showed a significant lower in-hospital mortality rate as compared with patients requiring mechanical ventilatory support (OR: 6.86, 95% CI: 5.39 - 268.74; P |
| Databáze: | OpenAIRE |
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