Relationship of intracellular creatine concentration and uptake to muscle mass in vivo
| Autor: | H. A. Leon, W. W. Hofmann, J. Butte |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Phosphocreatine Physiology Biological Transport Active Isometric exercise Biology Creatine Muscle hypertrophy chemistry.chemical_compound Internal medicine medicine Animals Denervation Muscle Denervation Muscles Hypertrophy Organ Size Cell Biology Rats Endocrinology chemistry Biochemistry Atrophy medicine.symptom Tetanic stimulation Intracellular Muscle Contraction Muscle contraction |
| Zdroj: | American Journal of Physiology-Cell Physiology. 235:C199-C203 |
| ISSN: | 1522-1563 0363-6143 |
| Popis: | Attempts have been made to evaluate the role of intracellular creatine in conditions leading to increased or decreased amounts of contractile protein in rat skeletal muscles. Resting concentrations of intracellular creatine ([Cr]i) and creatine phosphate ([CrP]i) were compared in gastrocnemius and soleus muscles with those immediately after a 20-s tetanic stimulation. The hydrolysis of creatine phosphate was the same after heavily and lightly loaded contractions, suggesting that hypertrophy of isometric exercise is not mediated by creatine. With atrophy after denervation or interruption of sciatic axoplasmic flow [Cr]i also remained unchanged, though [CrP]i and the rate of Cr uptake fell after denervation. The major change in adult red and white muscle bulk with unaltered [Cr]i suggests that the Cr sensitivity found by others in developing muscle in vitro has been supplemented or replaced by other control mechanisms. |
| Databáze: | OpenAIRE |
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