Isoflavonoids and coumarins from Glycyrrhiza uralensis: antibacterial activity against oral pathogens and conversion of isoflavans into isoflavan-quinones during purification
| Autor: | Markus Godejohann, Karine Feghali, Daneel Ferreira, Stefan Gafner, Daniel Grenier, Jacquelyn R. Villinski, Pavel Kessler, Chantal Bergeron, John H. Cardellina |
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| Rok vydání: | 2011 |
| Předmět: |
Pterocarpans
Pharmaceutical Science Microbial Sensitivity Tests Streptococcus sobrinus Analytical Chemistry Microbiology Streptococcus mutans Coumarins Germany Drug Discovery Humans Benzopyrans Glycyrrhiza uralensis Pharmacology biology Dose-Response Relationship Drug Fusobacterium nucleatum Organic Chemistry Pterocarpan Prevotella intermedia Quinones biology.organism_classification Isoflavones Anti-Bacterial Agents stomatognathic diseases Complementary and alternative medicine Sephadex Molecular Medicine Antibacterial activity Porphyromonas gingivalis |
| Zdroj: | Journal of natural products. 74(12) |
| ISSN: | 1520-6025 |
| Popis: | Phytochemical investigation of a supercritical fluid extract of Glycyrrhiza uralensis has led to the isolation of 20 known isoflavonoids and coumarins, and glycycarpan (7), a new pterocarpan. The presence of two isoflavan-quinones, licoriquinone A (8) and licoriquinone B (9), in a fraction subjected to gel filtration on Sephadex LH-20 is due to suspected metal-catalyzed oxidative degradation of licoricidin (1) and licorisoflavan A (2). The major compounds in the extract, as well as 8, were evaluated for their ability to inhibit the growth of several major oral pathogens. Compounds 1 and 2 showed the most potent antibacterial activities, causing a marked growth inhibition of the cariogenic species Streptococcus mutans and Streptococcus sobrinus at 10 μg/mL and the periodontopathogenic species Porphyromonas gingivalis (at 5 μg/mL) and Prevotella intermedia (at 5 μg/mL for 1 and 2.5 μg/mL for 2). Only 1 moderately inhibited growth of Fusobacterium nucleatum at the highest concentration tested (10 μg/mL). |
| Databáze: | OpenAIRE |
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