The role of long non‐coding RNAs in drug resistance of cancer
| Autor: | Da-wei Sun, He-da Zhang, Lin-hong Jiang, Siying Zhou, Jun-Chen Hou, Jian Li, Dan-Dan Wang, Shanliang Zhong, Jinhai Tang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Regulation of gene expression biology Tumor initiation Drug resistance Computational biology 030105 genetics & heredity Gene Expression Regulation Neoplastic MicroRNAs 03 medical and health sciences Transduction (genetics) 030104 developmental biology Histone Drug Resistance Neoplasm Interaction network Tumor progression Neoplasms Genetics biology.protein Humans RNA Long Noncoding Genomic imprinting Genetics (clinical) Signal Transduction |
| Zdroj: | Clinical Genetics. 99:84-92 |
| ISSN: | 1399-0004 0009-9163 |
| DOI: | 10.1111/cge.13800 |
| Popis: | Long non-coding RNAs (lncRNAs), a class of long RNAs, are longer than 200 nucleotides in length but lack protein-coding capacity. LncRNAs, as critical genomic regulators, are involved in genomic imprinting regulation, histone modification and gene expression regulation as well as tumor initiation and progression. However, it is also found that lncRNAs are associated with drug resistance in several types of cancer. Drug resistance is an important reason for clinical chemotherapy failure, and the molecular mechanism of tumor resistance is complex, which is a process of multi-cause, multi-gene and multi-signal transduction pathway interaction. Then comprehending the mechanisms of chemoresistance will help find ways to control the tumor progression effectively. Therefore, in this review, we will construct lncRNAs /drug resistance interaction network and shed light on the role of lncRNAs in drug resistance. |
| Databáze: | OpenAIRE |
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