Racial differences in patients' potassium concentrations during spironolactone therapy for heart failure
| Autor: | Larisa H. Cavallari, Lucy A. Fashingbauer, Mary Ross Southworth, Amber L. Beitelshees, Marlos A. G. Viana, Stephanie H. Dunlap, Vicki L. Groo, Randall E. Williams |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Angiotensin receptor Potassium medicine.medical_treatment Adrenergic beta-Antagonists chemistry.chemical_element Renal function Vasodilation Angiotensin-Converting Enzyme Inhibitors Spironolactone Gastroenterology White People chemistry.chemical_compound Internal medicine medicine Humans Pharmacology (medical) Diuretics Aged Retrospective Studies Heart Failure business.industry Middle Aged medicine.disease Black or African American Endocrinology chemistry Heart failure Dietary Supplements Female Diuretic business Homeostasis |
| Zdroj: | Pharmacotherapy. 24(6) |
| ISSN: | 0277-0008 |
| Popis: | Study Objective. To determine whether the effects of spironolactone on potassium homeostasis vary by race by comparing serum potassium concentrations and potassium supplement use in African-American and Caucasian patients receiving spironolactone for heart failure. Design. Retrospective medical record review. Setting. Two heart failure centers. Patients. Fifty African-American and 67 Caucasian patients with heart failure who were receiving a stable dosage of spironolactone in addition to standard heart failure therapy with an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker. Measurements and Main Results. Medical records of eligible patients were reviewed by pharmacists and physicians who specialize in heart failure management. No significant differences were observed in diuretic therapy or renal function between racial groups; however, African-Americans were receiving higher doses of ACE inhibitors. African-Americans had lower serum potassium concentrations (4.2 ± 0.4 vs 4.5 ± 0.5 mEq/L, p |
| Databáze: | OpenAIRE |
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