Extended Serum Lipid Profile Predicting Long-Term Survival in Patients Treated for Abdominal Aortic Aneurysms
| Autor: | Niku Oksala, Velipekka Suominen, Terho Lehtimäki, Niina Khan, Leo-Pekka Lyytikäinen, Tommi Kuorilehto, Antti Lehtomäki, Jahangir Khan, Ilkka Seppälä |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Lipoproteins Blood lipids Coronary Artery Disease 030204 cardiovascular system & hematology 030230 surgery Gastroenterology 03 medical and health sciences Aortic aneurysm chemistry.chemical_compound 0302 clinical medicine Risk Factors Internal medicine medicine Humans Stroke Aged Proportional Hazards Models Retrospective Studies medicine.diagnostic_test business.industry Proportional hazards model Cholesterol Cholesterol LDL Middle Aged medicine.disease Prognosis Surgery Treatment Outcome chemistry Regression Analysis lipids (amino acids peptides and proteins) Female business Lipid profile Lipoprotein Abdominal surgery Aortic Aneurysm Abdominal |
| Zdroj: | World journal of surgery. 42(4) |
| ISSN: | 1432-2323 |
| Popis: | Individuals treated for abdominal aortic aneurysms (AAAs) are high-risk patients in whom better risk prediction could improve survival. Contemporary serum lipid parameters, such as apolipoproteins and lipoprotein subfractions, may improve or complement the prognostic value of traditional serum lipids. The aim of this study was to ascertain the extended serum lipid profiles, long-term prognosis and their association in AAA patients. Altogether 498 patients treated for AAAs and with available serum lipid values were retrospectively analysed. Contemporary lipid parameters were estimated using a neural network model, the extended Friedewald formula. Younger age, smoking and urgent or emergency surgery were associated with an unfavourable, and coronary disease and previous stroke with a favourable lipid profile. In multivariable analysis—in addition to advanced age, aneurysm rupture, smoking, pulmonary disease and diabetes—high triglycerides and traditional LDL cholesterol were significant independent risk factors for mortality, HR 1.84 (95% CI 1.20–2.81) and 1.79 (95% CI 1.18–2.73), respectively, while higher EFW-IDL cholesterol was associated with better survival, HR 0.31 (95% CI 0.19–0.65). Including serum lipid parameters improved the prediction of 5-year survival (NRI = 17.7%, p = 0.016). Extended serum lipid parameters complement risk prediction of patients treated for AAAs. An unfavourable lipid profile is associated with treatment of AAA earlier in life and with inferior long-term survival. |
| Databáze: | OpenAIRE |
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