Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition
| Autor: | Alberto Diaz-Ruiz, Dolly Chowdhury, Eleonora Duregon, Oye Bosompra, Nathan L. Price, Paula Gonzalez Ericsson, Rafael de Cabo, Jonathan Kato, Arya Biragyn, Sandy Ng, Melissa Carpenter, Roberto Salgado, Michel Bernier, Monica Bodogai, Emeline Ragonnaud, Valter D. Longo, Sarah Wong, Laura C. D. Pomatto-Watson, Priya Krishna |
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| Rok vydání: | 2021 |
| Předmět: |
Calorie
Lung Neoplasms Cancer therapy Science General Physics and Astronomy Physiology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Article Metastasis Mice Breast cancer Cell Line Tumor medicine Tumor Microenvironment Animals Cause of death Caloric Restriction Multidisciplinary business.industry Cancer Caloric theory Mammary Neoplasms Experimental General Chemistry Fasting medicine.disease Primary tumor Tumor Burden Female business Carcinogenesis |
| Zdroj: | Nature Communications Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| ISSN: | 2041-1723 |
| Popis: | Cancer incidence increases with age and is a leading cause of death. Caloric restriction (CR) confers benefits on health and survival and delays cancer. However, due to CR’s stringency, dietary alternatives offering the same cancer protection have become increasingly attractive. Short cycles of a plant-based diet designed to mimic fasting (FMD) are protective against tumorigenesis without the chronic restriction of calories. Yet, it is unclear whether the fasting time, level of dietary restriction, or nutrient composition is the primary driver behind cancer protection. Using a breast cancer model in mice, we compare the potency of daily CR to that of periodic caloric cycling on FMD or an isocaloric standard laboratory chow against primary tumor growth and metastatic burden. Here, we report that daily CR provides greater protection against tumor growth and metastasis to the lung, which may be in part due to the unique immune signature observed with daily CR. Caloric restriction (CR) has been shown as an effective intervention to reduce tumorigenesis, but alternative less stringent dietary interventions have also been considered. Here, the authors show that in a murine model of breast cancer CR has a larger effect on preventing tumorigenesis and metastasis compared to periodic caloric cycling. |
| Databáze: | OpenAIRE |
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