Growth mechanisms of high-shear pelletisation

Autor:	C.P.F Guillaume, J.S. Ramaker, P Vonk, N.W.F Kossen, Herman Vromans
Přispěvatelé:	Faculty of Science and Engineering
Rok vydání:	1997
Předmět:	Coalescence (physics) High-shear mixer Chemistry High Shear Granulation Pellet Ultimate tensile strength Nucleation Pellets Pharmaceutical Science Mineralogy Composite material Pellet Dosage Form
Zdroj:	International Journal of Pharmaceutics, 93-102. Elsevier Bedrijfsinformatie b.v. STARTPAGE=93;ENDPAGE=102;ISSN=0378-5173;TITLE=International Journal of Pharmaceutics
ISSN:	0378-5173
Popis:	Two high-shear mixers, Gral 10 and Gral 25, were used to prepare pellets of microcrystalline cellulose and lactose, using water as binder liquid. Growth of pellets was investigated by measuring the pellet size distribution during the process. On the basis of the experiments the destructive nucleation growth mechanism was defined. Pelletisation was started with the formation of large primary nuclei. Small secondary nuclei were formed due to break-up of the primary nuclei. This nucleation process could be described by the comparison of the theoretical tensile strength of the nuclei and the dynamic impact pressure. Due to densification, the secondary nuclei became stronger and growth proceeded exponentially by coalescence. During the kneading stage, net growth was diminished until a steady state was observed. The mean pellet size did not change during the final stage of the kneading phase which resulted in a well-defined product.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0a525f0f7171d9d7d819b1f0d5e131 https://doi.org/10.1016/s0378-5173(97)00232-9 Zobrazit plný text záznamu Full Text from ScienceDirect