Color doppler imaging and plasma levels of endothelin-1 in low-tension glaucoma
| Autor: | N. Caramazza, R. Caramazza, Mauro Cellini, Vincenzo Profazio, G. L. Possati, M. Sbrocca |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Intraocular pressure medicine.medical_specialty Optic Disk Glaucoma Ciliary Arteries Ophthalmic Artery medicine.artery Ophthalmology medicine Humans Ultrasonography Doppler Color Intraocular Pressure Aged Endothelin-1 business.industry Blood flow Anatomy Middle Aged medicine.disease Endothelin 1 Ciliary arteries Low Tension Glaucoma Ophthalmic artery Female Visual Fields business Endothelin receptor Biomarkers Blood Flow Velocity Glaucoma Open-Angle |
| Zdroj: | Acta Ophthalmologica Scandinavica. 75:11-13 |
| ISSN: | 1395-3907 |
| DOI: | 10.1111/j.1600-0420.1997.tb00448.x |
| Popis: | Endothelin-1 (ET-1) is a potent vasoconstrictor peptide produced by vascular endothelin cells There are reports in the literature that ET-1 plasma levels are raised in low tension glaucoma (LTG). ET-1 plasma concentration and Color Doppler Imaging (CDI) evaluation in ophthalmic and posterior ciliary arteries were measured in 15 LTG patients and in 15 healthy subjects. The blood flow index recorded for the ophthalmic artery in normal subjects was a PSV of 36.646 +/- 6.611 cm/sec with RI of 0.717 +/- 0.019 while in the LTG patients it was 32.961 +/- 3.045 cm/sec (p < 0.003) with RI of 0.789 +/- 0.018 (p < 0.001). For the posterior ciliary arteries in the same two groups, we obtained a PSV of 13.878 +/- 4.149 cm/sec vs 8.720 +/- 1.645 cm/sec (p < 0.001) and an RI of 0.679 +/- 0.039 vs 0.722 +/- 0.024 (p < 0.001). The plasma ET-1 level in normal subjects was 1.720 +/- 0.174 pg while in LTG patients it was 2.947 +/- 0.217 pg (p < 0.001). On the basis of our experience, we think that GON and the visual field damage found in LTG can be attributed to an alteration in the endothelial self-regulating sections and consequent vascular insufficiency, particularly pronounced in the posterior ciliary arteries which, since it is these that provide the blood supply to the optic nerve head, leads to irreversible functional damage. |
| Databáze: | OpenAIRE |
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