Glycosylation-Based Serum Biomarkers for Cancer Diagnostics and Prognostics
| Autor: | Michelle Kilcoyne, Michael O'Dwyer, Marta Utratna, Lokesh Joshi, Alan Kirwan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Glycosylation
Proteome epididymis protein 4 Receptor ErbB-2 lcsh:Medicine Review Article Global Health Bioinformatics Chorionic Gonadotropin reactive alpha-fetoprotein epidermal-growth-factor chemistry.chemical_compound 0302 clinical medicine Carcinoembryonic antigen Serum biomarkers Lectins Neoplasms gestational trophoblastic disease Biomarker discovery Early Detection of Cancer chemistry.chemical_classification 0303 health sciences epithelial ovarian-cancer electrospray mass-spectrometry General Medicine Prognosis 3. Good health Prostate-specific antigen 030220 oncology & carcinogenesis Prognostics Kallikreins alpha-Fetoproteins CA-19-9 Antigen Biology Thyroglobulin General Biochemistry Genetics and Molecular Biology 03 medical and health sciences WAP Four-Disulfide Core Domain Protein 2 Adipokines human chorionic-gonadotropin Biomarkers Tumor Humans prostate-specific antigen Chitinase-3-Like Protein 1 Glycoproteins 030304 developmental biology hepatocellular-carcinoma patients Haptoglobins General Immunology and Microbiology Mucin-1 lcsh:R Membrane Proteins Proteins Carcinoembryonic Antigen chemistry CA-125 Antigen alpha 1-Antitrypsin biology.protein Cancer biomarkers multiple-myeloma patients Glycoprotein |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2015/490531 |
| Popis: | Cancer is the second most common cause of death in developed countries with approximately 14 million newly diagnosed individuals and over 6 million cancer-related deaths in 2012. Many cancers are discovered at a more advanced stage but better survival rates are correlated with earlier detection. Current clinically approved cancer biomarkers are most effective when applied to patients with widespread cancer. Single biomarkers with satisfactory sensitivity and specificity have not been identified for the most common cancers and some biomarkers are ineffective for the detection of early stage cancers. Thus, novel biomarkers with better diagnostic and prognostic performance are required. Aberrant protein glycosylation is well known hallmark of cancer and represents a promising source of potential biomarkers. Glycoproteins enter circulation from tissues or blood cells through active secretion or leakage and patient serum is an attractive option as a source for biomarkers from a clinical and diagnostic perspective. A plethora of technical approaches have been developed to address the challenges of glycosylation structure detection and determination. This review summarises currently utilised glycoprotein biomarkers and novel glycosylation-based biomarkers from the serum glycoproteome under investigation as cancer diagnostics and for monitoring and prognostics and includes details of recent high throughput and other emerging glycoanalytical techniques. |
| Databáze: | OpenAIRE |
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