Short‐ and long‐term follow‐up of thyroid dysfunction after allogeneic bone marrow transplantation without the use of preparative total body irradiation

Autor: Eliane Gluckman, Selim Aractingi, Gérard Socié, Marie-Helene Schlageter, Helene Esperou, Marie-Elisabeth Toubert, Patrick Vexiau, Jean-Didier Rain, Agnès Devergie, Patricia Ribaud, Jean‐Paul Beressi, Nathalie Parquet
Rok vydání: 1997
Předmět:
Zdroj: British Journal of Haematology. 98:453-457
ISSN: 1365-2141
0007-1048
DOI: 10.1046/j.1365-2141.1997.2433060.x
Popis: We studied the incidence and potential prognostic value of thyroid abnormalities after allogeneic bone marrow transplantation (BMT) without total body irradiation (TBI) conditioning. 77 consecutive patients who received a chemotherapy-alone-based conditioning regimen pretransplant were included. Free serum thyroxine (FT4), free serum triiodothyronine (FT3) and serum thyrotropin (TSH) levels were assayed before and 3 and 14 months after BMT. Patients were classified in three categories: normal thyroid profile if FT3 and FT4 were within the normal range and TSH was normal or low, peripheral thyroid insufficiency (PTI) if TSH was >4 mIU/l, or an ‘euthyroid sick syndrome’ (ETS) if FT3 and/or FT4 were low and TSH was normal or low. The incidence of thyroid dysfunction at 3 months was 57%, and 29% at 14 months. This was mostly due to the occurrence of ETS which was more frequent at 3 months (48%, 29/61) than at 14 months (19%, 9/48). Furthermore, at 3 months, survival was significantly lower in the ETS group (34.5%) than in the euthyroid group (96.2%), or in the PTI group (83.3%) (P
Databáze: OpenAIRE
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