Treatment of 161 Men with Symptomatic Late Onset Hypogonadism with Long-Acting Parenteral Testosterone Undecanoate: Effects on Body Composition, Lipids, and Psychosexual Complaints
| Autor: | Nakorn Tantirangsee, Sompol Permpongkosol, Krisada Ratana-Olarn |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Waist Urology Endocrinology Diabetes and Metabolism Hematocrit Gastroenterology Statistics Nonparametric Body Mass Index chemistry.chemical_compound Endocrinology Sex hormone-binding globulin Surveys and Questionnaires Internal medicine Health Status Indicators Humans Medicine Infusions Parenteral Testosterone Aged Aged 80 and over Analysis of Variance biology medicine.diagnostic_test Cholesterol business.industry Hypogonadism Age Factors Middle Aged medicine.disease Lipids Sexual Dysfunction Physiological Psychiatry and Mental health Reproductive Medicine chemistry Androgens Body Composition biology.protein Metabolic syndrome business Sexual function Body mass index |
| Zdroj: | The Journal of Sexual Medicine. 7:3765-3774 |
| ISSN: | 1743-6095 |
| Popis: | Introduction Elderly men may suffer from late-onset hypogonadism (LOH). The long-term effects of long-acting testosterone undecanoate (TU) in a large number of LOH men have not yet been reported. Aims We analyzed the effects of normalization of plasma testosterone (T) in LOH men. Methods The records of 161 men with LOH (baseline T 12 months. The mean duration of treatment was 90.6 weeks (54 to 150 weeks). Main Outcome Measures Body mass index (BMI), waist circumference, percentage body fat, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, prostate-specific antigen (PSA), and hematocrit were measured. Further the Aging Male Symptoms' scale (AMS) and the International Index of Erectile Function (IIEF-5 and 15) were scored. Results T therapy was associated with a significant decline in waist circumference ( P = 0.028) and percentage body fat ( P P = 0.005 and P = 0.024, respectively), with no significant changes of HDL cholesterol and triglycerides. The scores of sub-scales of AMS (psychological, somotovegetative and sexual factors) decreased ( P = 0.044, P = 0.200 and P = 0.071, respectively). The mean IIEF-5 ( P = 0.011) and IIEF-15 scores ( P = 0.021) improved significantly. Erectile function domain, orgasmic function domain, sexual desire domain, intercourse satisfaction domain, and overall satisfaction domain improved. Median PSA rose from 0.95 (0.640; 1.558) ng/mL to 1.480 (1.015; 2.275) ng/mL ( P 4 ng/mL (4.01–13.21). On biopsy there was no evidence for malignancy. The mean hematocrit level increased significantly from 42.3 ± 3.4% to 47.1 ± 3.8%. Conclusions Normalizing serum T in men with LOH resulted in improvement of the metabolic syndrome, mood and sexual functions and appeared acceptably safe. Permpongkosol S, Tantirangsee N, and Ratana-olarn, K. Treatment of 161 men with symptomatic late onset hypogonadism with long-acting parenteral testosterone undecanoate: Effects on body composition, lipids, and psychosexual complaints. |
| Databáze: | OpenAIRE |
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