Response to letter regarding article, 'Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy'
| Autor: | Francesca Stillitano, Martina Del Lungo, Peidong Fan, Benedetta Tosi, Corrado Poggesi, Magdi H. Yacoub, Alessandro Mugelli, Elisabetta Cerbai, Iacopo Olivotto, Laura Sartiani, Silvia Suffredini, Raffaele Coppini, Lina Yao, Cecilia Ferrantini, Chiara Tesi, Luiz Belardinelli |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Pathology business.industry Hypertrophic cardiomyopathy Action Potentials Cardiomyopathy Hypertrophic medicine.disease Piperazines Sodium current Physiology (medical) Internal medicine Cardiology medicine Humans Statistical analysis Acetanilides Female Myocytes Cardiac Cardiology and Cardiovascular Medicine business Sodium Channel Blockers |
| Zdroj: | Circulation. 128(10) |
| ISSN: | 1524-4539 |
| Popis: | We thank Sikkel et al for their appreciative letter, particularly focusing on the statistical approach used in our recent work.1 Indeed, physiological parameters of cells from human subjects exhibit considerable and intrinsic interindividual variability, at variance with inbred rodents. Thus, when working on human data, the use of hierarchical statistical analysis is not only the most valid option, but one could say it is mandatory to perform reliable comparisons between normal and diseased states. Hierarchical statistical analysis has been used previously in biomedical research involving human subjects,2 including a recent study comparing mechanical data from single myofibrils isolated from cardiac samples of patients with hypertrophic cardiomyopathy with donor hearts and secondary hypertrophy.3 … |
| Databáze: | OpenAIRE |
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